NPC 15669可提高内毒素处理小鼠的存活率并逆转白细胞减少症。 - Suppr

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超能文献

NPC 15669 enhances survival and reverses leukopenia in endotoxin-treated mice.

作者信息

Noronha-Blob L, Lowe V C, Weitzberg M, Burch R M

机构信息

Nova Pharmaceutical Corporation, Baltimore, MD 21224.

出版信息

Eur J Pharmacol. 1991 Jul 9;199(3):387-8. doi: 10.1016/0014-2999(91)90507-m.

DOI:10.1016/0014-2999(91)90507-m

PMID:1915587

Abstract

摘要

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NPC 15669 enhances survival and reverses leukopenia in endotoxin-treated mice.NPC 15669可提高内毒素处理小鼠的存活率并逆转白细胞减少症。

Eur J Pharmacol. 1991 Jul 9;199(3):387-8. doi: 10.1016/0014-2999(91)90507-m.

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Mice treated with a leumedin or antibody to Mac-1 to inhibit leukocyte sequestration survive endotoxin challenge.用亮抑素或抗Mac-1抗体处理以抑制白细胞滞留的小鼠能在内毒素攻击中存活。

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Anesthesiology. 2014 Apr;120(4):935-42. doi: 10.1097/ALN.0000000000000078.

Effect of some new prostaglandin synthetase inhibitors on the endotoxin induced mortality and biochemical changes in experimental animals.某些新型前列腺素合成酶抑制剂对实验动物内毒素诱导的死亡率及生化变化的影响

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[Antiinflammatory drugs inhibit the elevation of plasma CGRP concentration in endotoxin shock in rats].

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NPC 15669 blocks neutrophil CD18 increase and lung injury during cardiopulmonary bypass in pigs.NPC15669 可阻止心肺转流术期间猪中性粒细胞 CD18 的增加和肺损伤。

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A synthetic lipopolysaccharide-binding peptide based on the neutrophil-derived protein CAP37 prevents endotoxin-induced responses in conscious rats.一种基于中性粒细胞衍生蛋白CAP37的合成脂多糖结合肽可预防清醒大鼠内毒素诱导的反应。

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A new antiinflammatory compound, leumedin, inhibits modification of low density lipoprotein and the resulting monocyte transmigration into the subendothelial space of cocultures of human aortic wall cells.一种新的抗炎化合物柳胺素，可抑制低密度脂蛋白的修饰以及由此导致的单核细胞向人主动脉壁细胞共培养物的内皮下间隙迁移。

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The leukocyte recruitment inhibitor, NPC 15669 accelerates healing in acetic acid-induced colitis.白细胞募集抑制剂NPC 15669可加速醋酸诱导的结肠炎的愈合。

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