Apicella P, Ljungberg T, Scarnati E, Schultz W
Institut de Physiologie, Université de Fribourg, Switzerland.
Exp Brain Res. 1991;85(3):491-500. doi: 10.1007/BF00231732.
The sources of input and the behavioral effects of lesions and drug administration suggest that the striatum participates in motivational processes. We investigated the activity of single striatal neurons of monkeys in response to reward delivered for performing in a go-nogo task. A drop of liquid was given each time the animal correctly executed or withheld an arm movement in reaction to a visual stimulus. Of 1593 neurons, 115 showed increased activity in response to delivery of liquid reward in both go and nogo trials. Responding neurons were predominantly located in dorsal and ventromedial parts of anterior putamen, in dorsal and ventral caudate, and in nucleus accumbens. They were twice as frequent in ventral as compared to dorsal striatal areas. Responses occurred at a median latency of 337 ms and lasted for 525 ms, with insignificant differences between dorsal and ventral striatum. Reward responses differed from activity recorded in the face area of posterior putamen which varied synchronously with individual mouth movements. Responses were directly related to delivery of primary liquid reward and not to auditory stimuli associated with it. Most of them also occurred when reward was delivered outside of the task. These results demonstrate that neurons of dorsal and particularly ventral striatum are involved in processing information concerning the attribution of primary reward.
输入源以及损伤和药物给药的行为效应表明，纹状体参与动机过程。我们研究了猴子单个纹状体神经元在执行“去 - 不去”任务时对奖励做出反应的活动。每次动物根据视觉刺激正确执行或抑制手臂运动时，会给予一滴液体。在1593个神经元中，有115个在“去”和“不去”试验中对液体奖励的发放均表现出活动增加。反应性神经元主要位于前壳核的背侧和腹内侧部分、背侧和腹侧尾状核以及伏隔核。与背侧纹状体区域相比，它们在腹侧的出现频率是背侧的两倍。反应的中位潜伏期为337毫秒，持续525毫秒，背侧和腹侧纹状体之间无显著差异。奖励反应与后壳核面部区域记录到的活动不同，后壳核面部区域的活动与个体口部运动同步变化。反应与初级液体奖励的发放直接相关，而与与之相关的听觉刺激无关。大多数反应在任务之外给予奖励时也会出现。这些结果表明，背侧尤其是腹侧纹状体的神经元参与处理有关初级奖励归属的信息。
