Wadenvik H, Kutti J, Lindholm A
Department of Medicine, Ostra Hospital, University of Gothenburg, Sweden.
Eur J Haematol. 1991 Sep;47(3):192-6. doi: 10.1111/j.1600-0609.1991.tb01554.x.
111In labelled platelets and gamma camera scintigraphy were used for the study of the platelet loss during leukocyte removal filtration of stored platelets. Two different filters were examined, Imugard IG500 and Pall PL100, and platelet pools containing varying number of platelet concentrates were filtered. It was found that a sizeable amount of the platelets was trapped within the filter. Some of the trapped platelets could be recovered by rinsing the filters with normal saline. The most appropriate rinsing volume to recover lost platelets seemed to match with the "dead space" volume within the filter. It is concluded that radiolabelled platelets and gamma camera scintigraphy appears to be an excellent method to investigate the dynamic events of platelet loss during leukocyte removal filtration. This technique should be well applicable for the study of technological advances in filter construction.
利用¹¹¹铟标记的血小板和γ相机闪烁扫描技术研究储存血小板白细胞去除过滤过程中的血小板损失。检测了两种不同的过滤器，即Imugard IG500和颇尔PL100，并对含有不同数量血小板浓缩物的血小板池进行过滤。结果发现，大量血小板被困在过滤器内。通过用生理盐水冲洗过滤器，可以回收一些被困的血小板。回收丢失血小板的最合适冲洗体积似乎与过滤器内的“死腔”体积相匹配。得出的结论是，放射性标记血小板和γ相机闪烁扫描技术似乎是研究白细胞去除过滤过程中血小板损失动态事件的一种极好方法。该技术应非常适用于研究过滤器构造方面的技术进展。
