Peters A M, Saverymuttu S H, Malik F, Ind P W, Lavender J P
Thromb Haemost. 1985 Oct 30;54(3):595-8.
The intrahepatic kinetics of 111indium-labelled platelets have been studied using dynamic gamma camera scintigraphy immediately following injection. Platelets labelled in saline with 111In-oxine or 111In-acetylacetonate underwent rapidly reversible hepatic sequestration, indicating that they were "activated". Platelets labelled in plasma with 111In-tropolonate, however, did not display this phenomenon. On the assumption that plasma-labelled platelets display a normal initial bio-distribution, mean intrahepatic platelet transit time, as a factor of the transit time of 99m-Tc labelled red cells, was 1.45 +/- SE 0.12 (n = 6), implying the normal presence of a small intrahepatic platelet pool. Unlike the liver, transit through the spleen was not sensitive to the labelling medium; thus the mean intrasplenic transit time of plasma-labelled platelets was 9.3 +/- SE 0.7 min (n = 10), and of saline-labelled platelets 9.5 +/- SE 0.3 min (n = 8).
利用动态γ相机闪烁扫描技术，在注射后立即对111铟标记的血小板的肝内动力学进行了研究。用111铟-8-羟基喹啉或111铟-乙酰丙酮在生理盐水中标记的血小板经历了快速可逆的肝脏扣押，表明它们被“激活”。然而，用111铟-托酚酮在血浆中标记的血小板并未表现出这种现象。假设血浆标记的血小板显示出正常的初始生物分布，以99m锝标记的红细胞的转运时间为因子，肝内血小板平均转运时间为1.45±标准误0.12（n = 6），这意味着肝内存在一个小的血小板池是正常现象。与肝脏不同，通过脾脏的转运对标记介质不敏感；因此，血浆标记的血小板的脾内平均转运时间为9.3±标准误0.7分钟（n = 10），生理盐水标记的血小板为9.5±标准误0.3分钟（n = 8）。
