ArrayExpress和基因表达综合数据库中与暴露相关实验的DSSTox化学索引文件：实现毒理化学基因组学数据关联
DSSTox chemical-index files for exposure-related experiments in ArrayExpress and Gene Expression Omnibus: enabling toxico-chemogenomics data linkages.
作者信息
Williams-DeVane ClarLynda R, Wolf Maritja A, Richard Ann M
机构信息
National Center for Computational Toxicology, Office of Research and Development, US EPA, Research Triangle Park, NC 27711, USA.
出版信息
Bioinformatics. 2009 Mar 1;25(5):692-4. doi: 10.1093/bioinformatics/btp042. Epub 2009 Jan 21.
SUMMARY
The Distributed Structure-Searchable Toxicity (DSSTox) ARYEXP and GEOGSE files are newly published, structure-annotated files of the chemical-associated and chemical exposure-related summary experimental content contained in the ArrayExpress Repository and Gene Expression Omnibus (GEO) Series (based on data extracted on September 20, 2008). ARYEXP and GEOGSE contain 887 and 1064 unique chemical substances mapped to 1835 and 2381 chemical exposure-related experiment accession IDs, respectively. The standardized files allow one to assess, compare and search the chemical content in each resource, in the context of the larger DSSTox toxicology data network, as well as across large public cheminformatics resources such as PubChem (http://pubchem.ncbi.nlm.nih.gov).
AVAILABILITY
Data files and documentation may be accessed online at http://epa.gov/ncct/dsstox/.
摘要
分布式结构可搜索毒性（DSSTox）ARYEXP和GEOGSE文件是新发布的、带有结构注释的文件，包含ArrayExpress库和基因表达综合数据库（GEO）系列中与化学物质相关和与化学物质暴露相关的实验内容摘要（基于2008年9月20日提取的数据）。ARYEXP和GEOGSE分别包含887种和1064种独特化学物质，这些化学物质分别映射到1835个和2381个与化学物质暴露相关的实验登录号。这些标准化文件使人们能够在更大的DSSTox毒理学数据网络背景下，以及跨大型公共化学信息学资源（如PubChem，http://pubchem.ncbi.nlm.nih.gov），评估、比较和搜索每个资源中的化学物质含量。
可用性
数据文件和文档可在http://epa.gov/ncct/dsstox/在线获取。
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