Department of Clinical Sciences in Malmö, Diabetes and Cardiovascular disease-genetic epidemiology, Lund University, Malmö, Sweden.
Int J Obes (Lond). 2011 Aug;35(8):1041-9. doi: 10.1038/ijo.2010.263. Epub 2010 Dec 21.
We wanted to explore if FTO genotype interacts with fat intake, or leisure-time physical activity, on fat mass, lean mass and mortality.
Among 22,799 individuals (44-74 years) in the population-based Malmö diet and cancer cohort that were genotyped for rs9939609 in FTO and had information on dietary intake (from a modified diet history method) and no history of diabetes, cancer or cardiovascular disease, 2255 deaths (including 1100 cancer and 674 cardiovascular deaths) occurred during 12.0 years of follow-up. Leisure-time physical activity was determined from a list of 17 different physical activities in a questionnaire. Body composition was measured using bioelectric impedance method.
FTO genotype associated strongly with both fat mass and lean mass (P(trend) <1 × 10(-16) for both) but we found only significant interactions with fat intake, or physical activity, on fat mass (P(interaction)=0.01 and 0.004). No significant interaction between FTO genotype and fat intake (P(interaction)=0.72), or leisure-time physical activity (P(interaction)=0.07), on total mortality were observed. However, we observed a significant interaction between leisure-time physical activity and FTO genotype on cardiovascular mortality (P(interaction)=0.03). The highest vs lowest quintile of physical activity was associated with 46% (95% confidence interval, 17-64%) reduced cardiovascular mortality among TT-carriers (P(trend)=0.004), and 11% reduced cardiovascular mortality among A-allele carriers (P(trend)=0.68).
Our results indicate that FTO genotype associates with both fat mass and lean mass, but the level of fat intake and physical activity only modify the association with fat mass. In addition, FTO genotype may modify the association between physical activity and cardiovascular mortality.
我们希望探讨 FTO 基因型是否与脂肪摄入量或休闲时间体力活动相互作用，从而影响脂肪量、瘦肉量和死亡率。
在基于人群的马尔默饮食与癌症队列中，共有 22799 名（44-74 岁）个体进行了 FTO 基因 rs9939609 的基因分型，他们接受了饮食摄入（采用改良饮食史法）和无糖尿病、癌症或心血管疾病病史的信息调查，在 12.0 年的随访期间发生了 2255 例死亡（包括 1100 例癌症死亡和 674 例心血管死亡）。休闲时间体力活动是通过问卷中列出的 17 种不同体力活动来确定的。身体成分是通过生物电阻抗法测量的。
FTO 基因型与脂肪量和瘦肉量均有强烈关联（两者 P(trend)均<1×10(-16)），但仅发现与脂肪摄入量或体力活动在脂肪量上有显著的相互作用（P(interaction)=0.01 和 0.004）。FTO 基因型与脂肪摄入量（P(interaction)=0.72）或休闲时间体力活动（P(interaction)=0.07）之间没有显著的交互作用与总死亡率相关。然而，我们观察到在心血管死亡率方面，休闲时间体力活动和 FTO 基因型之间存在显著的相互作用（P(interaction)=0.03）。最高五分位与最低五分位的体力活动相比，TT 携带者的心血管死亡率降低了 46%（95%置信区间，17-64%）（P(trend)=0.004），A 等位基因携带者的心血管死亡率降低了 11%（P(trend)=0.68）。
我们的结果表明，FTO 基因型与脂肪量和瘦肉量均有关联，但脂肪摄入量和体力活动水平仅能调节与脂肪量的关联。此外，FTO 基因型可能会调节体力活动与心血管死亡率之间的关联。
