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Renal function and rate of hip bone loss in older men: the Osteoporotic Fractures in Men Study.老年男性的肾功能与髋部骨质流失率：男性骨质疏松性骨折研究
Osteoporos Int. 2008 Nov;19(11):1549-56. doi: 10.1007/s00198-008-0608-0. Epub 2008 Apr 5.
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Relationships of thoracic aortic wall calcification to cardiovascular risk factors: the Multi-Ethnic Study of Atherosclerosis (MESA).胸主动脉壁钙化与心血管危险因素的关系：动脉粥样硬化多民族研究（MESA）
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Effects of sevelamer hydrochloride and calcium carbonate on renal osteodystrophy in hemodialysis patients.盐酸司维拉姆和碳酸钙对血液透析患者肾性骨营养不良的影响。
J Am Soc Nephrol. 2008 Feb;19(2):405-12. doi: 10.1681/ASN.2006101089. Epub 2008 Jan 16.
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Progression of vascular calcifications is associated with greater bone loss and increased bone fractures.血管钙化的进展与更多的骨质流失和骨折增加有关。
Osteoporos Int. 2008 Aug;19(8):1161-6. doi: 10.1007/s00198-007-0539-1. Epub 2008 Jan 8.
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Bone morphogenetic proteins regulate osteoprotegerin and its ligands in human vascular smooth muscle cells.骨形态发生蛋白调节人血管平滑肌细胞中的骨保护素及其配体。
Endocrine. 2007 Aug;32(1):52-8. doi: 10.1007/s12020-007-9007-0. Epub 2007 Sep 29.
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Ethnic differences between extra-coronary measures on cardiac computed tomography: multi-ethnic study of atherosclerosis (MESA).心脏计算机断层扫描冠状动脉外测量的种族差异：动脉粥样硬化多民族研究（MESA）
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Serum levels of calcification inhibition proteins and coronary artery calcium score: comparison between transplantation and dialysis.血清钙化抑制蛋白水平与冠状动脉钙化积分：移植与透析的比较
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Factors involved in vascular calcification and atherosclerosis in maintenance haemodialysis patients.维持性血液透析患者血管钙化和动脉粥样硬化的相关因素。
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低骨量——血液透析患者冠状动脉钙化的一个危险因素。

Low bone volume--a risk factor for coronary calcifications in hemodialysis patients.

作者信息

Adragao Teresa, Herberth Johann, Monier-Faugere Marie-Claude, Branscum Adam J, Ferreira Anibal, Frazao Joao M, Dias Curto Jose, Malluche Hartmut H

机构信息

Nephrology Department, Santa Cruz Hospital, Lisbon, Portugal.

出版信息

Clin J Am Soc Nephrol. 2009 Feb;4(2):450-5. doi: 10.2215/CJN.01870408. Epub 2009 Jan 21.

DOI:10.2215/CJN.01870408
PMID:19158372
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2637600/
Abstract

BACKGROUND AND OBJECTIVES

There is increasing evidence that altered bone metabolism is associated with cardiovascular calcifications in patients with stage 5 chronic kidney disease on hemodialysis (HD). This study was conducted to evaluate the association between bone volume, turnover, and coronary calcifications in HD patients.

DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In a cross-sectional study, bone biopsies and multislice computed tomography were performed in 38 HD patients. Bone volume/total volume, activation frequency, and bone formation rate/bone surface were determined by histomorphometry and coronary calcifications were quantified by Agatston scores.

RESULTS

Prevalence of low bone turnover was 50% and of low bone volume was 16%. Among the studied traditional cardiovascular risk factors, only age was found to be associated with coronary calcifications. Lower bone volume was a significant risk factor for coronary calcifications during early years of HD, whereas this effect was not observed in patients with dialysis duration >6 yr. Histomorphometric parameters of bone turnover were not associated with coronary calcifications.

CONCLUSIONS

Low bone volume is associated with increased coronary calcifications in patients on HD.

摘要

背景与目的

越来越多的证据表明，在接受血液透析（HD）的5期慢性肾病患者中，骨代谢改变与心血管钙化有关。本研究旨在评估HD患者的骨体积、骨转换与冠状动脉钙化之间的关联。

设计、地点、参与者及测量方法：在一项横断面研究中，对38例HD患者进行了骨活检和多层计算机断层扫描。通过组织形态计量学确定骨体积/总体积、激活频率和骨形成率/骨表面积，并通过阿加斯顿评分对冠状动脉钙化进行量化。

结果

低骨转换的患病率为50%，低骨体积的患病率为16%。在研究的传统心血管危险因素中，仅发现年龄与冠状动脉钙化有关。较低的骨体积是HD早期冠状动脉钙化的重要危险因素，而在透析时间>6年的患者中未观察到这种效应。骨转换的组织形态计量学参数与冠状动脉钙化无关。

结论

HD患者的低骨体积与冠状动脉钙化增加有关。