健康受试者颈动脉衰老的磁共振成像
Magnetic resonance of carotid artery ageing in healthy subjects.
作者信息
Keenan Niall G, Locca Didier, Varghese Anitha, Roughton Michael, Gatehouse Peter D, Hooper James, Firmin David N, Pennell Dudley J
机构信息
Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, London, UK.
出版信息
Atherosclerosis. 2009 Jul;205(1):168-73. doi: 10.1016/j.atherosclerosis.2008.11.018. Epub 2008 Nov 27.
OBJECTIVE
To assess how the arterial wall of the carotid artery changes with age in normal subjects by cardiovascular magnetic resonance (CMR).
METHODS
Carotid CMR was performed in 100 normal subjects (10 per sex per decade) who were free of atherosclerotic risk factors and carotid atherosclerosis. Using three-dimensional computer modeling, the volumes of the arterial wall, lumen, and the total vessel were calculated, and the wall/outer wall (W/OW) ratio was derived.
RESULTS
Wall volume and total vessel volume increased significantly with age in both sexes (p<0.006), and this was more marked in males. The W/OW ratio also increased significantly with age (p<0.001). Lumen volume increased significantly with age in males (p<0.001), but not in females (p=0.1).
CONCLUSIONS
In normal subjects, carotid wall volume increases with age. In men, this vessel wall volume increase is associated with significant remodeling of the lumen and outer wall. These data relating normal carotid findings with ageing are important for further CMR studies of early atherosclerosis.
目的
通过心血管磁共振成像（CMR）评估正常受试者颈动脉动脉壁随年龄的变化情况。
方法
对100名无动脉粥样硬化危险因素和颈动脉粥样硬化的正常受试者（每十年每组性别各10人）进行颈动脉CMR检查。利用三维计算机建模，计算动脉壁、管腔和整个血管的体积，并得出壁/外壁（W/OW）比值。
结果
男性和女性的动脉壁体积和整个血管体积均随年龄显著增加（p<0.006），且男性更为明显。W/OW比值也随年龄显著增加（p<0.001）。男性管腔体积随年龄显著增加（p<0.001），而女性则无明显变化（p=0.1）。
结论
在正常受试者中，颈动脉壁体积随年龄增加。在男性中，这种血管壁体积增加与管腔和外壁的显著重塑有关。这些将正常颈动脉表现与衰老相关的数据对于进一步开展早期动脉粥样硬化的CMR研究具有重要意义。
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