Xie Shang, Luo Chongdai, Shan Xiaofeng, Zhao Shushan, He Jing, Cai Zhigang
Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, P.R. China.
Guanghua School and Hospital of Stomatology, Sun Yat-Sen University, Guangzhou, Guangdong 510055, P.R. China.
Mol Clin Oncol. 2016 Apr;4(4):660-666. doi: 10.3892/mco.2016.768. Epub 2016 Feb 5.
Numerous case-control studies have investigated whether the gene polymorphism is involved in the occurrence of oral squamous cell carcinoma (OSCC); however, the conclusions are inconsistent. In order to further explore the correlation and obtain a strong conclusion, a meta-analysis was performed to systematically assess the association between the MspI polymorphism and risk of OSCC. In the present meta-analysis, the odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were used to assess the association. The statistical analyses were performed with STATA 11.0 software. The heterogeneity was assessed by Q test and Itest. The final analysis included 10 studies of 1,505 cases and 1,967 controls. The overall results suggested that the MspI polymorphism was significantly associated with an increased risk of OSCC (CC+TC vs. TT: OR, 1.31; 95% CI, 1.01-1.70; P=0.043; CC vs. TC+TT: OR, 2.38; 95% CI, 1.58-3.58; P<0.001; CC vs. TT: OR, 2.52; 95% CI, 1.60-3.96; P<0.001; and C vs. T: OR, 1.45; 95% CI, 1.15-1.83; P<0.001). In a stratified analysis by ethnicity, a statistically significant correlation existed in the Asian population, but not mixed-race and Caucasian populations. In conclusion, despite several limitations, the present meta-analysis established that the MspI polymorphism may be a risk factor for OSCC, particularly among the Asian population.
众多病例对照研究探讨了该基因多态性是否与口腔鳞状细胞癌（OSCC）的发生有关；然而，结论并不一致。为了进一步探究相关性并得出有力结论，进行了一项荟萃分析，以系统评估MspI多态性与OSCC风险之间的关联。在本荟萃分析中，采用比值比（OR）及相应的95%置信区间（CI）来评估这种关联。使用STATA 11.0软件进行统计分析。通过Q检验和I检验评估异质性。最终分析纳入了10项研究，共1505例病例和1967例对照。总体结果表明，MspI多态性与OSCC风险增加显著相关（CC + TC与TT相比：OR，1.31；95% CI，1.01 - 1.70；P = 0.043；CC与TC + TT相比：OR，2.38；95% CI，1.58 - 3.58；P < 0.001；CC与TT相比：OR，2.52；95% CI，1.60 - 3.96；P < 0.001；C与T相比：OR，1.45；95% CI，1.15 - 1.83；P < 0.001）。在按种族进行的分层分析中，亚洲人群存在统计学显著相关性，而混血和白种人群则不存在。总之，尽管存在一些局限性，但本荟萃分析证实MspI多态性可能是OSCC的一个风险因素，尤其是在亚洲人群中。
