1. Department of General Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China.
2. Department of Oral and Maxillofacial Surgery, Peking University School and hospital of Stomatology, Beijing 100081, China.
J Cancer. 2015 Jan 22;6(4):302-9. doi: 10.7150/jca.11036. eCollection 2015.
CYP1A1 Ile462Val polymorphism might play a key role in pathogenesis of oral squamous cell carcinoma (OSCC). Many case-control studies have investigated the association between CYP1A1 Ile462Val polymorphism and OSCC susceptibility. However, the conclusions are inconsistent. To aim a convincible conclusion, we carried out a meta-analysis to systematically evaluate the association of CYP1A1 Ile462Val polymorphism with OSCC susceptibility. We searched Pubmed, Web of Science, Ovid and Embase databases for available publications. The odds ratio (OR) with the corresponding 95% confidence interval (95% CI) was carried out to estimate the association. A total of 13 papers including 1468 cases and 2183 controls were included, a significant increased OSCC risk was observed in recessive model (OR=1.64, 95% CI=1.08-2.49), but not other genetic models. Our results suggest that the homozygous variant of CYP1A1 Ile462Val might be a risk factor of OSCC.
CYP1A1 Ile462Val 多态性可能在口腔鳞状细胞癌（OSCC）的发病机制中起关键作用。许多病例对照研究已经调查了 CYP1A1 Ile462Val 多态性与 OSCC 易感性之间的关系。然而，结论并不一致。为了得出令人信服的结论，我们进行了荟萃分析，以系统评估 CYP1A1 Ile462Val 多态性与 OSCC 易感性的关系。我们检索了 Pubmed、Web of Science、Ovid 和 Embase 数据库中的可用文献。使用相应的 95%置信区间（95%CI）计算比值比（OR）来估计相关性。共纳入 13 篇文献，包括 1468 例病例和 2183 例对照，在隐性模型中观察到 OSCC 风险显著增加（OR=1.64，95%CI=1.08-2.49），但其他遗传模型则没有。我们的结果表明，CYP1A1 Ile462Val 的纯合变异可能是 OSCC 的一个危险因素。
