Clandinin M T, Cheema S, Field C J, Garg M L, Venkatraman J, Clandinin T R
Nutrition and Metabolism Research Group, University of Alberta, Edmonton, Canada.
FASEB J. 1991 Oct;5(13):2761-9. doi: 10.1096/fasebj.5.13.1916101.
Evidence indicates that principal features of the membrane involve structural organization of lipids in the form of a bilayer with functional proteins either bound to the bilayer surface or inserted into the bilayer and interacting within specific domains in the lipid milieux. In homeotherms, intrinsic and extrinsic factors apparently form the basis for determination of membrane lipid composition and thus membrane physicochemical properties. Moreover, many intrinsic metabolic controls, such as fatty acid desaturation and phospholipid biosynthesis, may be attenuated by change in the nature of the extrinsic or dietary influence. This review will focus on the role of dietary fat as a determinant of subcellular structural constituents to illustrate that feeding nutritionally adequate diets differing in fatty acid composition can induce physiological transitions in membrane function involving the activity of enzymes responsible for synthesis of membrane constituents, hormone-activated functions and expression of activity in the cell nucleus.
有证据表明，膜的主要特征涉及脂质以双层形式的结构组织，功能蛋白要么结合在双层表面，要么插入双层中，并在脂质环境的特定区域内相互作用。在恒温动物中，内在和外在因素显然构成了决定膜脂质组成以及膜物理化学性质的基础。此外，许多内在的代谢控制，如脂肪酸去饱和作用和磷脂生物合成，可能会因外在或饮食影响性质的改变而减弱。本综述将聚焦于膳食脂肪作为亚细胞结构成分决定因素的作用，以说明提供脂肪酸组成不同但营养充足的饮食，可诱导膜功能发生生理转变，这涉及负责膜成分合成的酶的活性、激素激活的功能以及细胞核中的活性表达。
