ω-3 和 ω-6 补充剂对表现出自闭症谱系障碍症状的早产儿语言的影响。
Effect of Omega-3 and -6 Supplementation on Language in Preterm Toddlers Exhibiting Autism Spectrum Disorder Symptoms.
机构信息
Center for Biobehavioral Health, The Research Institute at Nationwide Children's Hospital, 700 Children's Dr, Columbus, OH, 43205, USA.
Department of Pediatrics, College of Medicine, The Ohio State University, 700 Children's Dr, Columbus, OH, 43205, USA.
出版信息
J Autism Dev Disord. 2017 Nov;47(11):3358-3369. doi: 10.1007/s10803-017-3249-3.
Abstract
Delayed language development may be an early indicator of autism spectrum disorder (ASD). Early intervention is critical for children with ASD, and the present study presents pilot data on a clinical trial of omega-3 and -6 fatty acid supplementation and language development, a secondary trial outcome, in children at risk for ASD. We randomized 31 children to receive an omega-3 and -6 supplement or a placebo for 3 months, and measured their language abilities at baseline and after supplementation. Gesture use, but not word production, increased for children in the treatment group more than children in the placebo group. These results suggest possible effectiveness of omega-3 and -6 supplementation for language development in children at risk for ASD.
摘要
语言发育迟缓可能是自闭症谱系障碍（ASD）的早期指标。早期干预对 ASD 儿童至关重要，本研究介绍了一项关于ω-3 和 ω-6 脂肪酸补充剂和语言发育的临床试验的初步数据，这是次要的试验结果，针对有 ASD 风险的儿童。我们将 31 名儿童随机分为接受 ω-3 和 ω-6 补充剂或安慰剂的组，在基线和补充后测量他们的语言能力。与安慰剂组相比，治疗组的儿童手势使用增加，而词汇产生增加较少。这些结果表明，ω-3 和 ω-6 补充剂对有 ASD 风险的儿童的语言发育可能有效。
相似文献
1
Effect of Omega-3 and -6 Supplementation on Language in Preterm Toddlers Exhibiting Autism Spectrum Disorder Symptoms.ω-3 和 ω-6 补充剂对表现出自闭症谱系障碍症状的早产儿语言的影响。
J Autism Dev Disord. 2017 Nov;47(11):3358-3369. doi: 10.1007/s10803-017-3249-3.
2
ω-3 and ω-6 Fatty Acid Supplementation May Reduce Autism Symptoms Based on Parent Report in Preterm Toddlers.ω-3 和 ω-6 脂肪酸补充剂可能基于早产儿父母报告降低自闭症症状。
J Nutr. 2018 Feb 1;148(2):227-235. doi: 10.1093/jn/nxx047.
3
Effects of Omega-3-6-9 fatty acid supplementation on behavior and sleep in preterm toddlers with autism symptomatology: Secondary analysis of a randomized clinical trial.补充ω-3-6-9脂肪酸对有自闭症症状的早产幼儿行为和睡眠的影响：一项随机临床试验的二次分析
Early Hum Dev. 2022 Jun;169:105588. doi: 10.1016/j.earlhumdev.2022.105588. Epub 2022 May 19.
4
Randomized Controlled Trial of Omega-3 and -6 Fatty Acid Supplementation to Reduce Inflammatory Markers in Children with Autism Spectrum Disorder.随机对照试验研究ω-3 和 ω-6 脂肪酸补充剂对自闭症谱系障碍儿童炎症标志物的影响。
J Autism Dev Disord. 2022 Dec;52(12):5342-5355. doi: 10.1007/s10803-021-05396-9. Epub 2022 Jan 11.
5
Omega-3 and -6 fatty acid supplementation and sensory processing in toddlers with ASD symptomology born preterm: A randomized controlled trial.早产且有自闭症谱系障碍症状的幼儿补充ω-3和ω-6脂肪酸与感觉加工：一项随机对照试验。
Early Hum Dev. 2017 Dec;115:64-70. doi: 10.1016/j.earlhumdev.2017.09.015. Epub 2017 Sep 20.
6
ω-3 Fatty Acid Supplementation Does Not Affect Autism Spectrum Disorder in Children: A Systematic Review and Meta-Analysis.补充ω-3脂肪酸对儿童自闭症谱系障碍无影响：一项系统评价和荟萃分析。
J Nutr. 2017 Mar;147(3):367-376. doi: 10.3945/jn.116.242354. Epub 2017 Jan 11.
7
Vitamin D and omega-3 fatty acid supplements in children with autism spectrum disorder: a study protocol for a factorial randomised, double-blind, placebo-controlled trial.自闭症谱系障碍儿童补充维生素D和ω-3脂肪酸：一项析因随机、双盲、安慰剂对照试验的研究方案
Trials. 2016 Jun 23;17(1):295. doi: 10.1186/s13063-016-1428-8.
8
9
Omega-3 fatty acids in the management of autism spectrum disorders: findings from an open-label pilot study in Singapore.ω-3脂肪酸在自闭症谱系障碍管理中的应用：新加坡一项开放标签试点研究的结果
Eur J Clin Nutr. 2015 Aug;69(8):969-71. doi: 10.1038/ejcn.2015.28. Epub 2015 Mar 25.
10
A randomised controlled trial of vitamin D and omega-3 long chain polyunsaturated fatty acids in the treatment of irritability and hyperactivity among children with autism spectrum disorder.随机对照试验维生素 D 和欧米伽-3 长链多不饱和脂肪酸治疗自闭症谱系障碍儿童易激惹和多动。
J Steroid Biochem Mol Biol. 2019 Mar;187:9-16. doi: 10.1016/j.jsbmb.2018.10.017. Epub 2018 Oct 26.
引用本文的文献
1
Omega-3 fatty acids: multi-target mechanisms and therapeutic applications in neurodevelopmental disorders and epilepsy.Omega-3脂肪酸：在神经发育障碍和癫痫中的多靶点作用机制及治疗应用
Front Nutr. 2025 May 30;12:1598588. doi: 10.3389/fnut.2025.1598588. eCollection 2025.
2
Nutraceuticals in Psychiatric Disorders: A Systematic Review.精神障碍中的营养保健品：系统评价。
Int J Mol Sci. 2024 Apr 28;25(9):4824. doi: 10.3390/ijms25094824.
3
Evidence or no evidence for essential fatty acids in the treatment of autism spectrum disorders?治疗自闭症谱系障碍时必需脂肪酸有无证据支持？
Front Nutr. 2023 Aug 31;10:1251083. doi: 10.3389/fnut.2023.1251083. eCollection 2023.
4
Effects of Omega-3-6-9 fatty acid supplementation on behavior and sleep in preterm toddlers with autism symptomatology: Secondary analysis of a randomized clinical trial.补充ω-3-6-9脂肪酸对有自闭症症状的早产幼儿行为和睡眠的影响：一项随机临床试验的二次分析
Early Hum Dev. 2022 Jun;169:105588. doi: 10.1016/j.earlhumdev.2022.105588. Epub 2022 May 19.
5
Effect of Supplementation on Levels of Homovanillic and Vanillylmandelic Acids in Children with Autism Spectrum Disorders.补充剂对自闭症谱系障碍儿童高香草酸和香草扁桃酸水平的影响。
Metabolites. 2022 May 9;12(5):423. doi: 10.3390/metabo12050423.
6
Randomized Controlled Trial of Omega-3 and -6 Fatty Acid Supplementation to Reduce Inflammatory Markers in Children with Autism Spectrum Disorder.随机对照试验研究ω-3 和 ω-6 脂肪酸补充剂对自闭症谱系障碍儿童炎症标志物的影响。
J Autism Dev Disord. 2022 Dec;52(12):5342-5355. doi: 10.1007/s10803-021-05396-9. Epub 2022 Jan 11.
7
Neuroinflammation in Autism and Supplementation Based on Omega-3 Polyunsaturated Fatty Acids: A Narrative Review.自闭症中的神经炎症与基于ω-3 多不饱和脂肪酸的补充：叙述性综述。
Medicina (Kaunas). 2021 Aug 28;57(9):893. doi: 10.3390/medicina57090893.
8
Perinatal Dietary Polyunsaturated Fatty Acids in Brain Development, Role in Neurodevelopmental Disorders.围产期多不饱和脂肪酸在大脑发育中的作用及其与神经发育障碍的关系。
Nutrients. 2021 Apr 2;13(4):1185. doi: 10.3390/nu13041185.
9
Impact of polyunsaturated fatty acids on patient-important outcomes in children and adolescents with autism spectrum disorder: a systematic review.多不饱和脂肪酸对自闭症谱系障碍儿童和青少年患者重要结局的影响：系统评价。
Health Qual Life Outcomes. 2020 Feb 17;18(1):28. doi: 10.1186/s12955-020-01284-5.
10
Polyunsaturated Fatty Acids: What is Their Role in Treatment of Psychiatric Disorders?多不饱和脂肪酸：它们在治疗精神疾病方面的作用是什么？
Int J Mol Sci. 2019 Oct 23;20(21):5257. doi: 10.3390/ijms20215257.
本文引用的文献
1
ω-3 and ω-6 Fatty Acid Supplementation May Reduce Autism Symptoms Based on Parent Report in Preterm Toddlers.ω-3 和 ω-6 脂肪酸补充剂可能基于早产儿父母报告降低自闭症症状。
J Nutr. 2018 Feb 1;148(2):227-235. doi: 10.1093/jn/nxx047.
2
Linguistic and Non-Linguistic Semantic Processing in Individuals with Autism Spectrum Disorders: An ERP Study.自闭症谱系障碍个体的语言和非语言语义加工：一项事件相关电位研究。
J Autism Dev Disord. 2017 Mar;47(3):795-812. doi: 10.1007/s10803-016-2985-0.
3
Longchain polyunsaturated fatty acid supplementation in preterm infants.早产儿补充长链多不饱和脂肪酸
Cochrane Database Syst Rev. 2016 Dec 20;12(12):CD000375. doi: 10.1002/14651858.CD000375.pub5.
4
Executive functions and the ω-6-to-ω-3 fatty acid ratio: a cross-sectional study.执行功能与ω-6 与ω-3 脂肪酸比值：一项横断面研究。
Am J Clin Nutr. 2017 Jan;105(1):32-41. doi: 10.3945/ajcn.116.141390. Epub 2016 Nov 16.
5
Long-Chain Polyunsaturated Fatty Acids and Clinical Outcomes of Preterm Infants.长链多不饱和脂肪酸与早产儿的临床结局
Ann Nutr Metab. 2016;69 Suppl 1:35-44. doi: 10.1159/000448265. Epub 2016 Nov 15.
6
Communication Deficits and the Motor System: Exploring Patterns of Associations in Autism Spectrum Disorder (ASD).沟通障碍与运动系统：探索自闭症谱系障碍（ASD）中的关联模式
J Autism Dev Disord. 2017 Jan;47(1):155-162. doi: 10.1007/s10803-016-2934-y.
7
Neurobehaviour at term-equivalent age and neurodevelopmental outcomes at 2 years in infants born moderate-to-late preterm.中度至晚期早产儿足月相当年龄时的神经行为及2岁时的神经发育结局
Dev Med Child Neurol. 2017 Feb;59(2):207-215. doi: 10.1111/dmcn.13297. Epub 2016 Oct 24.
8
Omega-3 Fatty Acids and Cardiovascular Disease: Are There Benefits?欧米伽-3脂肪酸与心血管疾病：有益处吗？
Curr Treat Options Cardiovasc Med. 2016 Nov;18(11):69. doi: 10.1007/s11936-016-0487-1.
9
Omega 3/6 fatty acids for reading in children: a randomized, double-blind, placebo-controlled trial in 9-year-old mainstream schoolchildren in Sweden.欧米伽3/6脂肪酸对儿童阅读能力的影响：瑞典9岁主流学童的一项随机、双盲、安慰剂对照试验
J Child Psychol Psychiatry. 2017 Jan;58(1):83-93. doi: 10.1111/jcpp.12614. Epub 2016 Aug 22.
10
Omega-3 and Omega-6 Polyunsaturated Fatty Acid Levels and Correlations with Symptoms in Children with Attention Deficit Hyperactivity Disorder, Autistic Spectrum Disorder and Typically Developing Controls.注意力缺陷多动障碍、自闭症谱系障碍及正常发育对照儿童体内的Omega-3和Omega-6多不饱和脂肪酸水平及其与症状的相关性
PLoS One. 2016 May 27;11(5):e0156432. doi: 10.1371/journal.pone.0156432. eCollection 2016.
Zotero 插件