Clandinin M T, Field C J, Hargreaves K, Morson L, Zsigmond E
Can J Physiol Pharmacol. 1985 May;63(5):546-56. doi: 10.1139/y85-094.
Current concepts of the biomembrane will be extrapolated to membranes of homeotherms to illustrate the influence of the nature of dietary lipid in nutritionally complete diets on membrane polar head group content and fatty acid composition. Utilizing animal models, the controlling influence of dietary long chain fatty acids on major lipid constituents of the mitochondrial membrane in cardiac tissue, the plasma membrane of liver, and the synaptosomal membrane in brain can be demonstrated. Diet-induced alterations in membrane composition are associated with demonstrable changes in the function of specific membrane proteins. To illustrate this relationship, the effect of diet on mitochondrial ATPase activity and on a hormone receptor-stimulated function in the plasma membrane of the liver will be discussed. These observations suggest that the diet fat modulates enzyme functions in vivo by changing the surrounding lipid environment in the membrane.
当前生物膜的概念将被外推到家温动物的膜上，以说明营养完全的饮食中膳食脂质的性质对膜极性头部基团含量和脂肪酸组成的影响。利用动物模型，可以证明膳食长链脂肪酸对心脏组织线粒体膜、肝质膜和脑突触体膜的主要脂质成分的控制作用。饮食引起的膜成分变化与特定膜蛋白功能的明显改变有关。为了说明这种关系，将讨论饮食对线粒体ATP酶活性以及对肝质膜中激素受体刺激功能的影响。这些观察结果表明，膳食脂肪通过改变膜中的周围脂质环境在体内调节酶的功能。
