Stoss F, Meier-Ruge W
Chirurgische Abteilung, Krankenhaus Dornbirn.
Fortschr Med. 1991 Jul 20;109(21):424-8.
In patients with primary chronic constipation (n = 18) and diverticulosis of the sigmoid (n = 17) biopsies were examined enzyme-histochemically and the diagnosis of neuronal colonic dysplasia of the rectosigmoid was established. In eleven controls however a normal innervation was observed (p less than 0.001). Patients with neuronal colonic dysplasia usually failed to respond to conservative methods of treatment. Indication for surgery depended upon the duration and severity of the symptoms. The actual treatment--partial lateral submucous sphincterotomy, resection of the sigmoid colon or subtotal colectomy--was determined by the extent of the morphologically and functionally altered intestinal segment.
对原发性慢性便秘患者（n = 18）和乙状结肠憩室病患者（n = 17）进行活检，采用酶组织化学方法检查，并确诊为直肠乙状结肠神经元性结肠发育异常。然而，在11名对照者中观察到神经支配正常（p < 0.001）。患有神经元性结肠发育异常的患者通常对保守治疗方法无反应。手术指征取决于症状的持续时间和严重程度。实际的治疗方法——部分侧方黏膜下括约肌切开术、乙状结肠切除术或结肠次全切除术——由形态学和功能改变的肠段范围决定。
