Gershkovich Pavel, Wasan Kishor M, Barta Cheri A
Division of Pharmaceutics and Biopharmaceutics, The University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3.
Crit Rev Ther Drug Carrier Syst. 2008;25(6):545-84. doi: 10.1615/critrevtherdrugcarriersyst.v25.i6.20.
The introduction of combinatorial chemistry and the development of high-throughput techniques has significantly increased the amount of new active lipophilic molecular entities. As a result, the need for successful delivery of these lipophilic active compounds has also increased. One such method of delivery is through the use of advanced lipid-based drug delivery systems. Traditionally, the majority of reviews of lipid-based drug delivery systems were based on the oral administration field only. This review article focuses on the use of lipids in parenteral, dermal/ transdermal, and ocular drug delivery systems. Specific needs, considerations, approaches, and limitations in lipid-based drug delivery are discussed herein on the basis of the anatomical and physiological diversity of the target organs and systems.
组合化学的引入和高通量技术的发展显著增加了新型亲脂性活性分子实体的数量。因此，成功递送这些亲脂性活性化合物的需求也有所增加。一种这样的递送方法是通过使用先进的脂质体药物递送系统。传统上，大多数关于脂质体药物递送系统的综述仅基于口服给药领域。本文献综述聚焦于脂质体在肠胃外、皮肤/透皮和眼部药物递送系统中的应用。本文基于靶器官和系统的解剖学和生理学差异，讨论了脂质体药物递送中的特定需求、注意事项、方法和局限性。
