Department of Radiology, The Methodist Hospital Research Institute, Houston, TX 77030, USA.
Nanotechnology. 2011 Apr 15;22(15):155605. doi: 10.1088/0957-4484/22/15/155605. Epub 2011 Mar 10.
A critical issue for current liposomal carriers in clinical applications is their leakage of the encapsulated drugs that are cytotoxic to non-target tissues. We have developed partially polymerized liposomes composed of polydiacetylene lipids and saturated lipids. Cross-linking of the diacetylene lipids prevents the drug leakage even at 40 °C for days. These inactivated drug carriers are non-cytotoxic. Significantly, more than 70% of the encapsulated drug can be instantaneously released by a laser that matches the plasmon resonance of the tethered gold nanoparticles on the liposomes, and the therapeutic effect was observed in cancer cells. The remote activation feature of this novel drug delivery system allows for precise temporal and spatial control of drug release.
当前脂质体载体在临床应用中面临的一个关键问题是其包裹的药物会泄漏到对非靶组织具有细胞毒性。我们开发了由聚二乙炔脂质和饱和脂质组成的部分聚合脂质体。即使在 40°C 下数天，二乙炔脂质的交联也能防止药物泄漏。这些失活的药物载体没有细胞毒性。重要的是，超过 70%的包裹药物可以通过与脂质体上连接的金纳米粒子的等离子体共振相匹配的激光瞬间释放，并且在癌细胞中观察到了治疗效果。这种新型药物输送系统的远程激活特性允许对药物释放进行精确的时间和空间控制。
