Cho Jungsook, Nelson Thomas E, Bajova Hilda, Gruol Donna L
Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA.
J Neuroimmunol. 2009 Feb 15;207(1-2):92-100. doi: 10.1016/j.jneuroim.2008.12.007. Epub 2009 Jan 22.
The chemokine CXCL10 is expressed in the central nervous system (CNS) during neuroinflammatory conditions. Neurons express CXCR3, the receptor for CXCL10, and neuronal function has been shown to be altered by acute exposure to CXCL10. Little is known about the effects of chronic exposure to CXCL10 on neuronal function. Results from our studies show that chronic exposure of cultured rat hippocampal neurons to CXCL10 results in altered levels of protein for GABA and glutamate receptors and altered synaptic network activity. These effects of CXCL10 may contribute to altered CNS function that occurs in some chronic neuroinflammatory conditions.
趋化因子CXCL10在神经炎症状态下于中枢神经系统（CNS）中表达。神经元表达CXCL10的受体CXCR3，并且急性暴露于CXCL10已显示会改变神经元功能。关于长期暴露于CXCL10对神经元功能的影响知之甚少。我们的研究结果表明，将培养的大鼠海马神经元长期暴露于CXCL10会导致GABA和谷氨酸受体的蛋白质水平改变以及突触网络活动改变。CXCL10的这些作用可能导致某些慢性神经炎症状态下出现的中枢神经系统功能改变。
