白杨素衍生物与一氧化氮供体偶联物的合成及其促血管生成作用
Synthesis and promotion angiogenesis effect of chrysin derivatives coupled to NO donors.
作者信息
Peng Sheng-Ming, Zou Xiao-Qing, Ding Hua-Lan, Ding Yong-Lan, Lin Yuan-Bin
机构信息
Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, Hunan 411105, PR China.
出版信息
Bioorg Med Chem Lett. 2009 Feb 15;19(4):1264-6. doi: 10.1016/j.bmcl.2008.12.116. Epub 2009 Jan 10.
Two types of new chrysin derivatives were prepared by coupling NO donors of alkyl nitrate and furazan derivatives and were fully characterized by (1)H NMR and other techniques. These compounds were tested in human umbilical vein endothelial cells (HUVECs-12) and all the compounds exhibited cell proliferation. Notable effects of promoting angiogenesis were observed for all the modified compounds using chick chorioallantoic membrane (CAM) assay.
通过将硝酸烷基酯的一氧化氮供体与呋咱衍生物偶联制备了两种新型白杨素衍生物，并通过¹H NMR和其他技术对其进行了全面表征。这些化合物在人脐静脉内皮细胞（HUVECs-12）中进行了测试，所有化合物均表现出细胞增殖。使用鸡胚绒毛尿囊膜（CAM）试验观察到所有修饰化合物均具有促进血管生成的显著作用。
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