Talebi Marjan, Talebi Mohsen, Farkhondeh Tahereh, Simal-Gandara Jesus, Kopustinskiene Dalia M, Bernatoniene Jurga, Samarghandian Saeed
Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, 1991953381, Tehran, Iran.
Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, TX, 76019, USA.
Cancer Cell Int. 2021 Apr 15;21(1):214. doi: 10.1186/s12935-021-01906-y.
Chrysin has been shown to exert several beneficial pharmacological activities. Chrysin has anti-cancer, anti-viral, anti-diabetic, neuroprotective, cardioprotective, hepatoprotective, and renoprotective as well as gastrointestinal, respiratory, reproductive, ocular, and skin protective effects through modulating signaling pathway involved in apoptosis, oxidative stress, and inflammation. In the current review, we discussed the emerging cellular and molecular mechanisms underlying therapeutic indications of chrysin in various cancers. Online databases comprising Scopus, PubMed, Embase, ProQuest, Science Direct, Web of Science, and the search engine Google Scholar were searched for available and eligible research articles. The search was conducted by using MeSH terms and keywords in title, abstract, and keywords. In conclusion, experimental studies indicated that chrysin could ameliorate cancers of the breast, gastrointestinal tract, liver and hepatocytes, bladder, male and female reproductive systems, choroid, respiratory tract, thyroid, skin, eye, brain, blood cells, leukemia, osteoblast, and lymph. However, more studies are needed to enhance the bioavailability of chrysin and evaluate this agent in clinical trial studies.
白杨素已被证明具有多种有益的药理活性。白杨素通过调节参与细胞凋亡、氧化应激和炎症的信号通路，具有抗癌、抗病毒、抗糖尿病、神经保护、心脏保护、肝脏保护、肾脏保护以及胃肠道、呼吸道、生殖、眼部和皮肤保护作用。在当前的综述中，我们讨论了白杨素在各种癌症治疗指征背后新出现的细胞和分子机制。我们检索了包括Scopus、PubMed、Embase、ProQuest、Science Direct、Web of Science在内的在线数据库以及搜索引擎谷歌学术，以查找可用的合格研究文章。搜索使用了医学主题词以及标题、摘要和关键词中的关键词。总之，实验研究表明，白杨素可以改善乳腺癌、胃肠道癌、肝癌和肝细胞癌、膀胱癌、男性和女性生殖系统癌、脉络膜癌、呼吸道癌、甲状腺癌、皮肤癌、眼癌、脑癌、血细胞癌、白血病、成骨细胞癌和淋巴瘤。然而，需要更多的研究来提高白杨素的生物利用度，并在临床试验研究中评估这种药物。
