婴儿纤维性错构瘤：一项免疫组织化学和超微结构研究

Fibrous hamartoma of infancy: an immunohistochemical and ultrastructural study.

作者信息

Groisman G, Lichtig C

机构信息

Department of Pathology, Rambam Medical Center, Bat-Galim, Haifa, Israel.

出版信息

Hum Pathol. 1991 Sep;22(9):914-8. doi: 10.1016/0046-8177(91)90182-o.

DOI:10.1016/0046-8177(91)90182-o

PMID:1916752

Abstract

Fibrous hamartoma of infancy is an uncommon lesion of uncertain histogenesis. Three cases were studied by light microscopy, electron microscopy, and immunohistochemistry. Two histologic variants are presented. Ultrastructurally, fibroblasts and myofibroblasts were found in the fascicular-fibroblastic areas while primitive mesenchymal cells were found in the immature-appearing regions. Vimentin positivity was noted in both areas, whereas desmin and actin positivity was found mainly in the fascicular-fibroblastic regions. The lesion appears to fulfill the criteria for its characterization as "hamartoma."

摘要

婴儿纤维性错构瘤是一种组织发生不明的罕见病变。通过光学显微镜、电子显微镜和免疫组织化学对3例病例进行了研究。呈现了两种组织学变体。在超微结构上，在束状纤维母细胞区域发现了成纤维细胞和肌纤维母细胞，而在外观不成熟的区域发现了原始间充质细胞。两个区域均可见波形蛋白阳性，而结蛋白和肌动蛋白阳性主要见于束状纤维母细胞区域。该病变似乎符合将其表征为“错构瘤”的标准。