Greco M A, Schinella R A, Vuletin J C
Hum Pathol. 1984 Aug;15(8):717-23. doi: 10.1016/s0046-8177(84)80161-6.
The fine structures of three fibrous hamartomas of infancy were studied. All three components of these lesions were examined. The principal cells in the fibrous and myxoid areas were fibroblasts. Cells with stellate cytoplasmic projections were more prominent in myxoid areas. Myofibroblasts were abundant in two cases and not in the other. The adipose tissue component was formed by lipocytes and occasional preadipose fibroblasts. Blood vessels were more numerous in myxoid areas. Larger vessels were accompanied by smaller vessels and by clusters of cells with primitive junctions, suggesting early blood vessel formation. Some small vessels were surrounded by concentric layers of mesenchymal cells, as if attempting to form media. Electron microscopy seems to confirm the hamartomatous nature of fibrous hamartomas of infancy. The lesion appears to recapitulate the formation of blood vessels and fat, as seen in fetal tissues. Cellular myxoid areas showed prominent vasoformative proliferation, which decreased in the adipose tissue and was least prominent in the dense fibrous component. The latter may represent the end stage of the fibrous proliferation.
对三个婴儿期纤维性错构瘤的精细结构进行了研究。对这些病变的所有三个组成部分都进行了检查。纤维和黏液样区域的主要细胞是成纤维细胞。具有星状细胞质突起的细胞在黏液样区域更为突出。两例中肌成纤维细胞丰富，另一例则没有。脂肪组织成分由脂肪细胞和偶尔的前脂肪成纤维细胞组成。黏液样区域的血管更多。较大的血管伴有较小的血管以及具有原始连接的细胞簇，提示早期血管形成。一些小血管被同心层的间充质细胞包围，仿佛试图形成中膜。电子显微镜似乎证实了婴儿期纤维性错构瘤的错构瘤性质。该病变似乎重现了胎儿组织中血管和脂肪的形成过程。细胞黏液样区域显示出明显的血管形成性增殖，在脂肪组织中减少，在致密纤维成分中最不明显。后者可能代表纤维增殖的终末期。
