Fletcher C D, Powell G, van Noorden S, McKee P H
Department of Histopathology, St. Thomas' Hospital Medical School, London, UK.
Histopathology. 1988 Jan;12(1):65-74. doi: 10.1111/j.1365-2559.1988.tb01917.x.
Fibrous hamartoma of infancy is an uncommon lesion, the histogenesis and biological nature of which are uncertain. Ten cases have been studied by light microscopy, mucin histochemistry and immunohistochemistry. The typical histological features are presented. The presence of hyaluronic acid and of chondroitin-4- and -6-sulphate and keratan sulphate has been demonstrated in different components of the tumour. Vimentin positivity was noted in the undifferentiated and fibroblastic components. The implications of these findings are discussed. Whether the lesion merits the designation of hamartoma or is, in fact, a benign neoplasm remains obscure.
婴儿纤维性错构瘤是一种罕见的病变，其组织发生和生物学性质尚不确定。通过光学显微镜、黏液组织化学和免疫组织化学对10例病例进行了研究。呈现了典型的组织学特征。已在肿瘤的不同成分中证实存在透明质酸、硫酸软骨素-4和-6以及硫酸角质素。波形蛋白在未分化和成纤维成分中呈阳性。讨论了这些发现的意义。该病变是否值得被称为错构瘤，或者实际上是一种良性肿瘤，仍然不清楚。
