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[肝素对内源性和外源性高脂血症情况下血脂的影响]

[Effect of heparin on blood lipids under conditions of endo- and exogenous hyperlipemia].

作者信息

Lipovetskiĭ B M, Ryzhov V M

出版信息

Kardiologiia. 1976 Mar;16(3):123-7.

PMID:191678
Abstract

In 15 patients suffering from ischemic heart disease and in 5 healthy individuals (controls) the dynamics of the blood lipids content (NEFA, triglycerides and atherogenic lipoproteins) was followed up on an empty stomach, during a 18-hour fasting, after carbohydrate and fat loadings, before and after intravenous administration of heparin. Data on a quick and abrupt rise of the NEFA level and a falling triglycerides concentration, and also on a certain decline in the content of atherogenic lipoproteins following administration of heparin were obtained. In atherosclerotic patients the development of hypertriglyceridemia in response to introduction of glucose and a prolonged rise in the level of triglycerides following a fat loading were recorded. Intravenous administration of heparin with carbohydrates and fat loads contributes in atherosclerotic patients to a rapid fall of the blood plasma tryglycerides concentration.

摘要

对15例缺血性心脏病患者和5名健康个体(对照组),在空腹、禁食18小时、碳水化合物和脂肪负荷后、静脉注射肝素前后,对血脂含量(游离脂肪酸、甘油三酯和致动脉粥样硬化脂蛋白)的动态变化进行了跟踪研究。获得了关于游离脂肪酸水平快速急剧升高、甘油三酯浓度下降以及注射肝素后致动脉粥样硬化脂蛋白含量有所下降的数据。在动脉粥样硬化患者中,记录到葡萄糖引入后高甘油三酯血症的发生以及脂肪负荷后甘油三酯水平的持续升高。在动脉粥样硬化患者中,静脉注射肝素加碳水化合物和脂肪负荷有助于血浆甘油三酯浓度迅速下降。

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