Kim Young Dae, Choi Hye Yeon, Jung Yo Han, Nam Chung Mo, Yang Jae Hoon, Cho Han Jin, Nam Hyo Suk, Lee Kyung-Yul, Heo Ji Hoe
Department of Neurology, National Core Research Center for Nanomedical Technology, Yonsei University College of Medicine, Seoul, Korea.
Neuroepidemiology. 2009;32(3):201-7. doi: 10.1159/000195690. Epub 2009 Jan 24.
The prevalence of extracranial (EC) and intracranial (IC) atherosclerosis varies among races. Although several studies have sought to identify specific vascular risk factors that are associated with EC or IC atherosclerosis, the exact relationships are uncertain. This study aimed to determine if there are any specific risk factors for EC or IC atherosclerosis.
For this study, we considered 3,349 consecutive patients who had been entered into a stroke registry between January 1999 and June 2007. After the exclusion of patients who had not undergone angiography, patients with cardiac sources of embolism or other causes of stroke, and non-Koreans, we had a total of 2,169 patients of single ethnicity with an angiographic analysis. Patients with atherosclerosis in both the IC and EC arteries (856 patients) were excluded. Finally, we identified 1,313 patients who had EC atherosclerosis (EC group, n = 256), IC atherosclerosis (IC group, n = 566) or normal angiographic findings (no-lesion group, n = 488). The frequency of risk factors and the demographic parameters were compared among these groups.
When compared to the normal group, the IC group was associated with older age and hypertension, and the EC group was associated with older age, higher initial blood sugar and low-density lipoprotein cholesterol levels. However, in a direct comparison between the IC and EC groups, we did not observe any significant risk factors or variables except for a higher frequency of males and higher total cholesterol levels in the EC group.
Vascular risk factors may not be major determinants of location for atherosclerosis in the EC or IC arteries.
颅外（EC）和颅内（IC）动脉粥样硬化的患病率在不同种族之间存在差异。尽管有几项研究试图确定与EC或IC动脉粥样硬化相关的特定血管危险因素，但确切关系尚不确定。本研究旨在确定EC或IC动脉粥样硬化是否存在任何特定危险因素。
在本研究中，我们纳入了1999年1月至2007年6月期间连续登记入卒中登记系统的3349例患者。排除未接受血管造影的患者、有心源性栓塞或其他卒中原因的患者以及非韩国人后，我们共有2169例单一民族患者进行血管造影分析。排除IC和EC动脉均有动脉粥样硬化的患者（856例）。最后，我们确定了1313例患有EC动脉粥样硬化（EC组，n = 256）、IC动脉粥样硬化（IC组，n = 566）或血管造影结果正常（无病变组，n = 488）的患者。比较了这些组之间危险因素的频率和人口统计学参数。
与正常组相比，IC组与年龄较大和高血压相关，EC组与年龄较大、初始血糖较高和低密度脂蛋白胆固醇水平较高相关。然而，在IC组和EC组的直接比较中，除了EC组男性频率较高和总胆固醇水平较高外，我们未观察到任何显著的危险因素或变量。
血管危险因素可能不是EC或IC动脉粥样硬化部位的主要决定因素。
