Yang Wen-Jie, Wong Ka-Sing, Chen Xiang-Yan
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Sha Tin, Hong Kong.
J Stroke. 2017 Sep;19(3):249-260. doi: 10.5853/jos.2016.01956. Epub 2017 Sep 6.
Intracranial atherosclerosis is one of the leading causes of ischemic stroke and occurs more commonly in patients of Asian, African or Hispanic origin than in Caucasians. Although the histopathology of intracranial atherosclerotic disease resembles extracranial atherosclerosis, there are some notable differences in the onset and severity of atherosclerosis. Current understanding of intracranial atherosclerotic disease has been advanced by the high-resolution magnetic resonance imaging (HRMRI), a novel emerging imaging technique that can directly visualize the vessel wall pathology. However, the pathological validation of HRMRI signal characteristics remains a key step to depict the plaque components and vulnerability in intracranial atherosclerotic lesions. The purpose of this review is to describe the histological features of intracranial atherosclerosis and to state current evidences regarding the validation of MR vessel wall imaging with histopathology.
颅内动脉粥样硬化是缺血性卒中的主要病因之一，在亚洲、非洲或西班牙裔患者中比在白种人中更常见。尽管颅内动脉粥样硬化疾病的组织病理学与颅外动脉粥样硬化相似，但在动脉粥样硬化的发病和严重程度方面存在一些显著差异。高分辨率磁共振成像（HRMRI）是一种新兴的成像技术，能够直接观察血管壁病变，目前对颅内动脉粥样硬化疾病的认识因该技术而取得进展。然而，HRMRI信号特征的病理验证仍然是描绘颅内动脉粥样硬化病变中斑块成分和易损性的关键步骤。本综述的目的是描述颅内动脉粥样硬化的组织学特征，并阐述目前关于磁共振血管壁成像与组织病理学验证的证据。
