罗素蝰蛇毒的致死和出血活性——多价、单价及类毒素抗血清的中和作用
Lethal and haemorrhagic activity of Russell's Viper venom--neutralization by polyvalent, monovalent and toxoid antiserum.
作者信息
Chakrabarty D, Gomes A, Lahiri S C, Nag Chaudhuri A K
机构信息
Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
出版信息
Indian J Exp Biol. 1991 May;29(5):456-9.
Lethal and haemorrhagic activity of Russell's Viper venom was compared against polyvalent bivalent commercial antiserum and monovalent antiserum raised in rabbit. Formaldehyde-detoxified venom offered 7-fold protection against lethal activity and 12.5-fold against haemorrhagic activity of the venom. Whole venom and formaldehyde-detoxified venom along with Freund's complete adjuvant, injected in rabbits produced high titre antiserum. Amongst all the six antiserum tested, the monovalent antiserum raised in rabbit, showed maximum precipitating bands in immunogeldiffusion and immunoelectrophoresis. The toxoid-antiserum offered maximum protection against the venom-induced lethality and the monovalent antiserum offered maximum protection against haemorrhagic activity.
将罗素蝰蛇毒液的致死和出血活性与多价二价商业抗血清以及在兔体内产生的单价抗血清进行了比较。甲醛解毒的毒液对毒液的致死活性提供了7倍的保护，对出血活性提供了12.5倍的保护。将全毒液和甲醛解毒的毒液与弗氏完全佐剂一起注射到兔体内，产生了高效价抗血清。在所有测试的六种抗血清中，在兔体内产生的单价抗血清在免疫凝胶扩散和免疫电泳中显示出最多的沉淀带。类毒素抗血清对毒液诱导的致死性提供了最大保护，而单价抗血清对出血活性提供了最大保护。
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