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普通牙膏和美白牙膏对牛牙釉质体外再矿化的影响。

Effects of regular and whitening dentifrices on remineralization of bovine enamel in vitro.

作者信息

Kielbassa Andrej M, Tschoppe Peter, Hellwig Elmar, Wrbas Karl-Thomas

机构信息

Department of Operative Dentistry and Periodontology, University School of Dental Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.

出版信息

Quintessence Int. 2009 Feb;40(2):103-12.

Abstract

OBJECTIVE

To compare in vitro the remineralizing effects of different regular dentifrices and whitening dentifrices (containing pyrophosphates) on predemineralized enamel.

METHOD AND MATERIALS

Specimens from 84 bovine incisors were embedded in epoxy resin, partly covered with nail varnish, and demineralized in a lactic acid solution (37 degrees C, pH 5.0, 8 days). Parts of the demineralized areas were covered with nail varnish, and specimens were randomly assigned to 6 groups. Subsequently, specimens were exposed to a remineralizing solution (37 degrees C, pH 7.0, 60 days) and brushed 3 times a day (1:3 slurry with remineralizing solution) with 1 of 3 regular dentifrices designed for anticaries (group 1, amine; group 2, sodium fluoride) or periodontal (group 3, amine/stannous fluoride) purposes or whitening dentifrice containing pyrophosphates (group 4, sodium fluoride). An experimental dentifrice (group 5, without pyrophosphates/fluorides) and a whitening dentifrice (group 6, monofluorophosphate) served as controls. Mineral loss and lesion depths were evaluated from contact microradiographs, and intergroup comparisons were performed using the closed-test procedure (alpha =.05).

RESULTS

Compared to baseline, specimens brushed with the dentifrices containing stannous/amine fluorides revealed significant mineral gains and lesion depth reductions (P < .05). Concerning the reacquired mineral, the whitening dentifrice performed worse than the regular dentifrices (P > .05), while mineral gain, as well as lesion depth, reduction was negligible with the control groups.

CONCLUSION

Dentifrices containing pyrophosphates perform worse than regular dentifrices but do not necessarily affect remineralization. Unless remineralizing efficacy is proven, whitening dentifrices should be recommended only after deliberate consideration in caries-prone patients.

摘要

目的

在体外比较不同普通牙膏和美白牙膏(含焦磷酸盐)对预脱矿釉质的再矿化作用。

方法和材料

从84颗牛切牙获取标本,嵌入环氧树脂中,部分用指甲油覆盖,然后在乳酸溶液(37℃,pH 5.0,8天)中脱矿。将部分脱矿区域用指甲油覆盖,标本随机分为6组。随后,将标本置于再矿化溶液(37℃,pH 7.0,60天)中,每天用3种用于防龋(第1组,胺;第2组,氟化钠)或牙周(第3组,胺/氟化亚锡)目的的普通牙膏或含焦磷酸盐的美白牙膏(第4组,氟化钠)之一刷牙3次(与再矿化溶液按1:3配成糊剂)。一种实验牙膏(第5组,不含焦磷酸盐/氟化物)和一种美白牙膏(第6组,单氟磷酸钠)作为对照。从接触式显微放射照片评估矿物质流失和病变深度,采用封闭检验程序进行组间比较(α = 0.05)。

结果

与基线相比,用含氟化亚锡/胺氟化物的牙膏刷牙的标本显示矿物质显著增加,病变深度减小(P < 0.05)。关于再获得的矿物质,美白牙膏的效果比普通牙膏差(P > 0.05),而对照组的矿物质增加以及病变深度减小可忽略不计。

结论

含焦磷酸盐的牙膏效果比普通牙膏差,但不一定影响再矿化。除非再矿化效果得到证实,否则对于易患龋齿的患者,仅在慎重考虑后才应推荐使用美白牙膏。

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