Rozdzinski E, Kern W, Schmeiser T, Kurrle E
Dept. of Hematology and Oncology, Ulm University Hospital, Germany.
Infection. 1991 Jul-Aug;19(4):201-4. doi: 10.1007/BF01644945.
During a six-year period 23 patients with isolation of Corynebacterium jeikeium (formerly known as Corynebacterium group JK) from one or more blood cultures at a university hospital were identified. Cases occurred sporadically without time- or ward-related clustering. Review of the cases showed that most infections were nosocomial, that most of the patients had underlying malignant disease, had a chronic intravascular catheter implanted, had been pretreated with antibiotics, and were neutropenic at the time the blood cultures were drawn. Patients with only one versus those with more than one positive blood culture differed in some important aspects. Patients with only one positive blood culture were less likely to have acute leukemia, had significantly higher neutrophil counts and a shorter duration of preceding antibiotic treatment, and all had other probable causes of infection and fever. The mortality also appeared to be lower in these patients. Despite the possibility of increasing frequency of blood cultures positive for C. jeikeium, severe infections due to this organism continue to be largely confined to neutropenic patients with hematologic malignancy.
在六年期间，一所大学医院里有23例患者从一份或多份血培养中分离出杰氏棒状杆菌（以前称为JK棒状杆菌属）。病例呈散发性，没有与时间或病房相关的聚集性。对这些病例的回顾显示，大多数感染是医院感染，大多数患者患有潜在的恶性疾病，植入了慢性血管内导管，接受过抗生素预处理，并且在采集血培养时存在中性粒细胞减少症。仅有一次血培养阳性的患者与有不止一次血培养阳性的患者在一些重要方面存在差异。仅有一次血培养阳性的患者患急性白血病的可能性较小，中性粒细胞计数显著更高，先前抗生素治疗的持续时间更短，并且都有其他可能的感染和发热原因。这些患者的死亡率似乎也较低。尽管杰氏棒状杆菌血培养阳性的频率可能增加，但这种微生物引起的严重感染在很大程度上仍然局限于患有血液系统恶性肿瘤的中性粒细胞减少患者。
