Bayston R, Compton C, Richards K
Institute of Child Health, University of London, England.
J Clin Microbiol. 1994 Jul;32(7):1705-9. doi: 10.1128/jcm.32.7.1705-1709.1994.
Corynebacterium spp. are responsible for an important minority of cases of colonization of cerebrospinal fluid shunts used for the treatment of hydrocephalus. In common with coagulase-negative staphylococci, they present a serious therapeutic problem because they are often resistant to multiple antibiotics. We studied the morphologies of coryneforms in colonized hydrocephalus shunts removed from patients and observed extracellular slime similar in appearance to that seen in coagulase-negative staphylococci. We also studied a series of such isolates from other cases of hydrocephalus shunt colonization using an established laboratory model and consistently observed slime production in these shunts as well. We propose that this might be a further reason for failure to eradicate these organisms without shunt removal as well as a factor in their pathogenesis in device-related infections.
棒状杆菌属是导致用于治疗脑积水的脑脊液分流管定植的少数重要病例的病因。与凝固酶阴性葡萄球菌一样，它们带来了严重的治疗问题，因为它们往往对多种抗生素耐药。我们研究了从患者身上取出的定植于脑积水分流管中的棒状菌形态，观察到其细胞外黏液在外观上与凝固酶阴性葡萄球菌中的黏液相似。我们还使用一个既定的实验室模型研究了一系列来自其他脑积水分流管定植病例的此类分离株，并始终观察到这些分流管中也有黏液产生。我们提出，这可能是在不摘除分流管的情况下无法根除这些微生物的另一个原因，也是它们在与装置相关感染发病机制中的一个因素。
