杰氏棒状杆菌败血症中抗体反应的特征分析。

Clark I, Burnie J P, Coke A P, Matthews R C, Oppenheim B A

Department of Molecular Microbiology, Manchester University Medical School.

Epidemiol Infect. 1990 Oct;105(2):229-36. doi: 10.1017/s095026880004783x.

Corynebacterium jeikeium causes septicaemia in neutropenic patients usually after colonizing intravenous lines. This paper reports the results of immunoblotting sera from 14 patients with a C. jeikeium septicaemia. Recovery from the septicaemia was associated with production of both IgM and IgG against antigenic bands of 50, 52 and 110 kDa. Antibody against the 110 kDa band was present in controls but the antibody against the 50 and 52 kDa was specific to those patients who had on-going or previous C. jeikeium infection. A case of C. jeikeium endocarditis is also presented and here recovery was associated with seroconversion to the 50 and 52 kDa bands.

杰氏棒状杆菌通常在定植于静脉导管后，可导致中性粒细胞减少患者发生败血症。本文报告了对14例杰氏棒状杆菌败血症患者血清进行免疫印迹的结果。败血症的康复与针对50、52和110 kDa抗原条带产生IgM和IgG相关。对照组中存在针对110 kDa条带的抗体，但针对50和52 kDa的抗体是那些患有持续性或既往杰氏棒状杆菌感染患者所特有的。本文还介绍了1例杰氏棒状杆菌心内膜炎病例，该病例的康复与血清转化为针对50和52 kDa条带的抗体相关。