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在人T淋巴细胞样CCRF-CEM细胞的多药耐药变体中，淋巴细胞归巢受体基因的表达丧失。

Expression of lymphocyte homing receptor gene is lost in multi-drug-resistant variants of human T-lymphoblastoid CCRF-CEM cells.

作者信息

Cianfriglia M, Yassen A, Tombesi M, Samoggia P, Barca S, Caserta M

机构信息

Laboratorio di Immunologia, Istituto Superiore di Sanità, Rome, Italy.

出版信息

Int J Cancer. 1991 Sep 30;49(3):394-7. doi: 10.1002/ijc.2910490314.

DOI:10.1002/ijc.2910490314
PMID:1917137
Abstract

The 2.2-kb human cDNA clone PBL32, encoding for the lymphocyte homing receptor (LHR) was used to study the expression of this determinant in multi-drug-resistant (MDR) variants of human T-lymphoblastoid CCRF-CEM (CEM) cells. LHR is significantly associated with the drug-sensitive phenotype, its expression being progressively and quantitatively reduced in MDR variants of CEM cells according to the extent of drug resistance.

摘要

编码淋巴细胞归巢受体（LHR）的2.2kb人cDNA克隆PBL32，被用于研究该决定簇在人T淋巴母细胞CCRF-CEM（CEM）细胞的多药耐药（MDR）变体中的表达。LHR与药物敏感表型显著相关，根据耐药程度，其在CEM细胞的MDR变体中的表达逐渐且定量地降低。

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