United States Naval Medical Research Center Detachment, Public Health Training Program (AGL) and Virology Program (SMM), Lima, Perú.
PLoS Negl Trop Dis. 2009;3(1):e371. doi: 10.1371/journal.pntd.0000371. Epub 2009 Jan 27.
Neurocysticercosis accounts for 30%-50% of all late-onset epilepsy in endemic countries. We assessed the clustering patterns of Taenia solium human cysticercosis seropositivity and seizures around tapeworm carriers in seven rural communities in Peru.
The presence of T. solium-specific antibodies was defined as one or more positive bands in the enzyme-linked immunoelectrotransfer blot (EITB). Neurocysticercosis-related seizures cases were diagnosed clinically and had positive neuroimaging or EITB.
Eleven tapeworm carriers were identified by stool microscopy. The seroprevalence of human cysticercosis was 24% (196/803). Seroprevalence was 21% >50 m from a carrier and increased to 32% at 1-50 m (p = 0.047), and from that distance seroprevalence had another significant increase to 64% at the homes of carriers (p = 0.004). Seizure prevalence was 3.0% (25/837) but there were no differences between any pair of distance ranges (p = 0.629, Wald test 2 degrees of freedom).
CONCLUSION/SIGNIFICANCE: We observed a significant human cysticercosis seroprevalence gradient surrounding current tapeworm carriers, although cysticercosis-related seizures did not cluster around carriers. Due to differences in the timing of the two outcomes, seroprevalence may reflect recent T. solium exposure more accurately than seizure frequency.
在流行国家，神经囊虫病占所有迟发性癫痫的 30%-50%。我们评估了在秘鲁七个农村社区中，绦虫携带者周围猪带绦虫人体囊虫病血清阳性和癫痫发作的聚集模式。
存在 T. solium 特异性抗体被定义为酶联免疫电转移印迹（EITB）中一个或多个阳性条带。神经囊虫病相关的癫痫发作病例通过临床诊断，并具有阳性的神经影像学或 EITB。
通过粪便显微镜发现了 11 例绦虫携带者。人体囊虫病的血清阳性率为 24%（196/803）。距离携带者>50 m 的血清阳性率为 21%，而在 1-50 m 之间则增加到 32%（p = 0.047），距离携带者的住所，血清阳性率再次显著增加至 64%（p = 0.004）。癫痫发作的患病率为 3.0%（25/837），但在任何一对距离范围内均无差异（p = 0.629，Wald 检验自由度为 2）。
结论/意义：尽管囊虫病相关的癫痫发作没有聚集在携带者周围，但我们观察到在当前绦虫携带者周围存在显著的人体囊虫病血清阳性率梯度。由于两种结果的时间不同，血清阳性率可能比癫痫发作频率更准确地反映近期 T. solium 的暴露情况。
