中国湖北宫颈癌及癌前病变中单一和多种人乳头瘤病毒类型的流行情况

Prevalence of single and multiple human papillomavirus types in cervical cancer and precursor lesions in Hubei, China.

作者信息

Cai Hong Bing, Ding Xiao Hua, Chen Chang Chun

机构信息

Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan, PR China.

出版信息

Oncology. 2009;76(3):157-61. doi: 10.1159/000195885. Epub 2009 Jan 28.

DOI:10.1159/000195885

PMID:19174613

Abstract

OBJECTIVE

The objective of this study was to establish the prevalence and type distribution of human papillomavirus (HPV) in cervical cancer and cervical intraepithelial neoplasia (CIN) in Hubei, China.

METHODS

A total of 112 patients with cervical cancer and 60 CIN II-III samples were obtained from women undergoing biopsy or surgery. HPV and typing were examined by the polymerase chain reaction (PCR) and sequencing.

RESULTS

HPV DNA was detected in 105 patients with cervical cancer (93.75%), HPV 16 being detected in 91 (81.25%) cases, and HPV 58 in 7 (6.25%) cases. HPV DNA was detected in 50 patients with CIN II-III (83.33%), HPV 16 being detected in 37 (61.67%) cases, HPV 58 in 5 cases (8.33%). HPV 18 was not common in this study. About 11% cervical cancer and 8.33% CIN II-III specimens exhibited multiple infections (p = 0.79).

CONCLUSION

The high prevalence of HPV 16 in Hubei, China, deserves attention as it has important implications for the usefulness of vaccine and the choice of diagnostic methods.

摘要

目的

本研究旨在确定中国湖北地区宫颈癌及宫颈上皮内瘤变（CIN）中人类乳头瘤病毒（HPV）的流行情况及类型分布。

方法

从接受活检或手术的女性中获取了112例宫颈癌患者及60例CIN II - III样本。采用聚合酶链反应（PCR）及测序技术检测HPV及其分型。

结果

105例宫颈癌患者（93.75%）检测到HPV DNA，其中91例（81.25%）检测到HPV 16，7例（6.25%）检测到HPV 58。50例CIN II - III患者（83.33%）检测到HPV DNA，其中37例（61.67%）检测到HPV 16，5例（8.33%）检测到HPV 58。HPV 18在本研究中不常见。约11%的宫颈癌及8.33%的CIN II - III样本表现为多重感染（p = 0.79）。