中华人民共和国北京地区的人乳头瘤病毒感染：一项基于人群的研究。
Human papillomavirus infection in Beijing, People's Republic of China: a population-based study.
作者信息
Zhao R, Zhang W Y, Wu M H, Zhang S W, Pan J, Zhu L, Zhang Y P, Li H, Gu Y S, Liu X Z
机构信息
Beijing Obstetric and Gynecology Hospital, Capital Medical University, No. 251 Yao Jiayuan Road, Chaoyang District, Beijing 100026, China.
出版信息
Br J Cancer. 2009 Nov 3;101(9):1635-40. doi: 10.1038/sj.bjc.6605351. Epub 2009 Sep 29.
BACKGROUND
No recent data exist on human papillomavirus (HPV) infection in Beijing, People's Republic of China.
MATERIALS AND METHOD
We interviewed and examined a representative, randomly selected sample of 5552 sexually active women aged 25-54 years. Cervical cell samples were analysed for HPV DNA by a MY09/11-based PCR assay.
RESULTS
Human papillomavirus prevalence was 6.7% overall and 4.8% among women without cervical abnormalities. Of the 21 subtypes identified, HPV16 was the commonest type (2.6% overall; 39.1% of HPV-positive women), followed by HPV 58 (1.0%), 33 (0.8%), 43 (0.7%) and 56 (0.7%). High-risk HPV types predominated in all age groups. Human papillomavirus prevalence was highest in young to middle-aged women. Marital status, number of husband's sexual partners, age at sexual debut and nulligravidity were all associated with being HPV positive.
CONCLUSIONS
In our survey, HPV 16, HPV 58 and HPV 33 were the most prevalent HPV types in Beijing, indicating the potential for the prophylactic HPV 16/18 vaccine in China.
背景
目前尚无关于中华人民共和国北京地区人乳头瘤病毒（HPV）感染的最新数据。
材料与方法
我们对5552名年龄在25至54岁之间、具有代表性且随机选取的性活跃女性进行了访谈和检查。通过基于MY09/11的聚合酶链反应检测法对宫颈细胞样本进行HPV DNA分析。
结果
HPV总体感染率为6.7%，宫颈无异常的女性感染率为4.8%。在鉴定出的21种亚型中，HPV16是最常见的类型（总体为2.6%；HPV阳性女性中占39.1%），其次是HPV 58（1.0%）、33（0.8%）、43（0.7%）和56（0.7%）。高危HPV类型在所有年龄组中占主导地位。HPV感染率在年轻至中年女性中最高。婚姻状况、丈夫的性伴侣数量、首次性行为年龄和未孕均与HPV阳性相关。
结论
在我们的调查中，HPV 16、HPV 58和HPV 33是北京地区最常见的HPV类型，这表明在中国HPV 16/18预防性疫苗具有应用潜力。
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