Department of Medical Laboratory, West China Second University Hospital, Sichuan University, 610041ChengDu, China.
Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, 610041ChengDu, China.
Epidemiol Infect. 2021 Apr 12;149:e95. doi: 10.1017/S0950268821000741.
The present study attempted to analyse human papillomavirus (HPV) genotype distribution and its association with cervical cytology results in women in western China. The present retrospective analysis was performed in 1089 female outpatients with a positive HPV test result who had undergone a cervical cytology test at the gynaecological clinic, West China Second Hospital, Sichuan University, China, between January 2014 and December 2016. Of the 1089 patients with HPV infection, multiple HPV genotypes were detected in 220 patients (20.20%). Among the 1368 HPV genotypes detected, 1145 (83.70%) were high-risk subtypes. The most common genotypes were HPV-52 (18.64%), HPV-16 (16.59%), HPV-58 (13.23%), HPV-18 (6.80%), HPV-56 (5.56%) and HPV-59 (5.56%). Cervical cytology revealed abnormal cells in 430 (39.49%) patients. The most common diagnoses were atypical squamous cells of undetermined significance (ASC-US; 236 cases, 54.88%), low-grade squamous intraepithelial lesions (LSIL; 151 cases, 35.12%), high-grade squamous intraepithelial lesions (HSIL; 63 cases, 14.65%) and atypical glandular cells (AGC; 21 cases, 4.88%). HPV-66 was significantly associated (P = 0.037) with ASC; HPV-52 and HPV-56 were significantly associated with LSIL (P = 0.009 and 0.026, respectively); HPV-16 (P < 0.001), HPV-33 (P = 0.014) and HPV-58 (P = 0.003) were significantly associated with HSIL; and HPV-16 (P = 0.005) was significantly associated with AGC. HPV-16, HPV-52 and HPV-58 are associated with different diagnoses in patients with positive cervical cytological findings.
本研究旨在分析中国西部地区女性人乳头瘤病毒（HPV）基因型分布及其与宫颈细胞学结果的关系。本回顾性分析纳入了 2014 年 1 月至 2016 年 12 月在中国四川大学华西第二医院妇科诊所因 HPV 检测阳性而接受宫颈细胞学检查的 1089 例女性门诊患者。在 1089 例 HPV 感染患者中，220 例（20.20%）患者检测到多种 HPV 基因型。在检测到的 1368 种 HPV 基因型中，1145 种（83.70%）为高危亚型。最常见的基因型是 HPV-52（18.64%）、HPV-16（16.59%）、HPV-58（13.23%）、HPV-18（6.80%）、HPV-56（5.56%）和 HPV-59（5.56%）。宫颈细胞学检查显示 430 例（39.49%）患者的细胞异常。最常见的诊断是不能明确意义的非典型鳞状细胞（ASC-US；236 例，54.88%）、低级别鳞状上皮内病变（LSIL；151 例，35.12%）、高级别鳞状上皮内病变（HSIL；63 例，14.65%）和非典型腺细胞（AGC；21 例，4.88%）。HPV-66 与 ASC 显著相关（P=0.037）；HPV-52 和 HPV-56 与 LSIL 显著相关（P=0.009 和 0.026）；HPV-16（P<0.001）、HPV-33（P=0.014）和 HPV-58（P=0.003）与 HSIL 显著相关；HPV-16（P=0.005）与 AGC 显著相关。HPV-16、HPV-52 和 HPV-58 与宫颈细胞学阳性患者的不同诊断有关。
