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[大环内酯类药物的类型及特点]

[Types and characteristics of macrolides].

作者信息

Płusa Tadeusz

机构信息

Wojskowy Instytut Medyczny w Warszawie, Klinika Chorób Wewnetrznych, Pneumonologii i Alergologii CSK MON.

出版信息

Pol Merkur Lekarski. 2008 Nov;25(149):403-7.

Abstract

Macrolide antibiotics have been used to treat acute and chronic inflammation in the respiratory tract based on their antibacterial activity. Now it is well known that macrolides down-regulate damaging prolonged inflammation as well as increase mucus clearance and decrease bacterial virulence. Some drug interactions with macrolides have been documented in clinical trials mainly connected with their influence on liver function. Adverse reactions are few and self-limited when used at the recommended dosage.

摘要

基于其抗菌活性,大环内酯类抗生素已被用于治疗呼吸道的急慢性炎症。现在众所周知,大环内酯类药物可下调有害的持续性炎症,同时增加黏液清除并降低细菌毒力。在临床试验中已记录了一些与大环内酯类药物的药物相互作用,主要与其对肝功能的影响有关。按推荐剂量使用时,不良反应很少且为自限性。

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