通过一锅串联反应简便地立体选择性合成氟化黄烷酮衍生物。
Facile stereoselective synthesis of fluorinated flavanone derivatives via a one-pot tandem reaction.
作者信息
Cui Haifeng, Li Peng, Chai Zhuo, Zheng Changwu, Zhao Gang, Zhu Shizheng
机构信息
Laboratory of Modern Synthetic Organic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, People's Republic of China.
出版信息
J Org Chem. 2009 Feb 6;74(3):1400-2. doi: 10.1021/jo8023818.
PMID:19178359
Abstract
A series of fluorinated flavanones were synthesized in moderate to good yields with excellent diastereoselectivities under mild reaction conditions via a one-pot tandem procedure involving a proline-catalyzed Knoevenagel condensation, a Michael addition, and an electrophilic fluorination by NFSI.
摘要
通过一锅串联反应，在温和的反应条件下，以脯氨酸催化的Knoevenagel缩合、迈克尔加成以及NFSI亲电氟化反应，以中等至良好的产率和优异的非对映选择性合成了一系列氟化黄烷酮。
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