Departamento de Química Orgánica, Universidad de Valencia, E-46100 Burjassot, Spain.
Org Lett. 2010 Aug 6;12(15):3484-7. doi: 10.1021/ol101318t.
A novel one-pot tandem asymmetric Hantzsch-type process has been employed to generate fluorinated 1,4-dihydropyridines (1,4-DHPs) as single diastereoisomers. It involves the condensation of (R)-(+)-allyl p-tolyl sulfoxide, fluorinated nitriles, and alkyl propiolates, giving access to a new family of enantiomerically pure fluorine-containing 1,4-DHPs.
采用 novel one-pot tandem asymmetric Hantzsch-type process 合成了作为单一非对映异构体的氟化 1,4-二氢吡啶 (1,4-DHPs)。该过程涉及 (R)-(+)-烯丙基对甲苯亚砜、氟化腈和丙炔酸酯的缩合，为具有手性纯氟的 1,4-DHPs 提供了一个新的家族。
