Cashmore R G, Harcourt-Brown T R, Freeman P M, Jeffery N D, Granger N
The Queen's Veterinary School Hospital, Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, United Kingdom.
Aust Vet J. 2009 Jan-Feb;87(1):45-50. doi: 10.1111/j.1751-0813.2008.00379.x.
Three dogs were referred to The Queen's Veterinary School Hospital at University of Cambridge for chronic behavioural or locomotor disorders associated with pain. All three had been unsuccessfully treated with conventional analgesics, including non-steroidal anti-inflammatory drugs, glucocorticoids and opiate agonists, prior to referral, with minimal or no response. They were investigated by neurological examination plus conventional ancillary diagnostic tests and therapeutic drug trials. Ruling out other causes of pain and applying previously well-described criteria, each case was diagnosed as consistent with neuropathic pain, a poorly recognised condition in domestic dogs. Treatment with the tricyclic antidepressant drug, amitriptyline, or the antiepileptic drug, gabapentin, resulted in either a dramatic improvement or full resolution of clinical signs in all cases.
三只狗因与疼痛相关的慢性行为或运动障碍被转诊至剑桥大学女王兽医学院医院。转诊前，这三只狗均接受过包括非甾体抗炎药、糖皮质激素和阿片类激动剂在内的传统镇痛药治疗，但均未成功，反应极小或无反应。它们接受了神经学检查以及传统辅助诊断测试和治疗药物试验。排除其他疼痛原因并应用先前详细描述的标准后，每例病例均被诊断为符合神经性疼痛，这在犬类中是一种认识不足的病症。使用三环类抗抑郁药阿米替林或抗癫痫药加巴喷丁进行治疗后，所有病例的临床症状均得到显著改善或完全缓解。
