Crociolli Giulianne Carla, Cassu Renata Navarro, Barbero Rafael Cabral, Rocha Thalita Leone A, Gomes Denis Robson, Nicácio Gabriel Montoro
Department of Veterinary Surgery and Anesthesiology, Faculty of Veterinary Medicine, Universidade do Oeste Paulista, Presidente Prudente, Brazil.
J Vet Med Sci. 2015 Aug;77(8):1011-5. doi: 10.1292/jvms.14-0602. Epub 2015 Mar 29.
This study aimed to evaluate the analgesic efficacy of gabapentin as an adjuvant for postoperative pain management in dogs. Twenty dogs undergoing mastectomy were randomized to receive perioperative oral placebo or gabapentin (10 mg/kg). All dogs were premedicated with intramuscular acepromazine (0.03 mg/kg) and morphine (0.3 mg/ kg). Anesthesia was induced with propofol (4 mg/kg) intravenously and maintained with isoflurane. Intravenous meloxicam (0.2 mg/kg) was administered preoperatively. Postoperative analgesia was evaluated for 72 hr. Rescue analgesia was provided with intramuscular morphine (0.5 mg/kg). Dogs in the Placebo group received significantly more morphine doses than the Gabapentin group (P=0.021), despite no significant differences in pain scores. Perioperative gabapentin reduced the postoperative morphine requirements in dogs after mastectomy.
本研究旨在评估加巴喷丁作为犬术后疼痛管理辅助药物的镇痛效果。二十只接受乳房切除术的犬被随机分为两组，分别在围手术期口服安慰剂或加巴喷丁（10毫克/千克）。所有犬均肌肉注射乙酰丙嗪（0.03毫克/千克）和吗啡（0.3毫克/千克）进行术前用药。通过静脉注射丙泊酚（4毫克/千克）诱导麻醉，并用异氟醚维持麻醉。术前静脉注射美洛昔康（0.2毫克/千克）。术后72小时评估镇痛效果。使用肌肉注射吗啡（0.5毫克/千克）提供急救镇痛。尽管疼痛评分无显著差异，但安慰剂组的犬接受的吗啡剂量明显多于加巴喷丁组（P=0.021）。围手术期使用加巴喷丁可降低犬乳房切除术后的术后吗啡需求量。
