Department of Pediatrics, Maulana Azad Medical College and LN Hospital, New Delhi, India.
Indian Pediatr. 2009 Sep;46(9):794-6. Epub 2009 Jan 1.
We present a retrospective analysis of clinical profile of 100 children admitted to a Government hospital at Delhi between April 2005 and December 2006 with group A meningococcal infection. Maximum children presented in late winter and spring. Younger children were less affected (5% children < 1 year). Fever (86%), vomiting (64%) and rash (63%) were the most common presenting symptoms. All children presented within 5 days of onset of symptoms and 52% within 24 hours. 67 % children had meningococcal meningitis; 20% had meningococcemia; and 13% had both. Overall mortality was 17%. Altered sensorium and shock at presentation significantly increased the mortality. All culture positive cases had group A Neisseria meningitides. All meningococcal isolates were sensitive to penicillin/ampicillin, ciprofloxacin, ceftriaxone, chloramphenicol and erythromycin except, one each resistant to ampicillin and erythromycin.
我们对 2005 年 4 月至 2006 年 12 月在德里一家政府医院住院的 100 名 A 群脑膜炎球菌感染患儿的临床特征进行了回顾性分析。大多数患儿出现在冬末春初。年龄较小的患儿受影响较小（<1 岁的患儿占 5%）。发热（86%）、呕吐（64%）和皮疹（63%）是最常见的首发症状。所有患儿均在症状出现后 5 天内就诊，52%在 24 小时内就诊。67%的患儿患有脑膜炎球菌性脑膜炎；20%患有脑膜炎球菌血症；13%同时患有这两种疾病。总死亡率为 17%。发病时出现意识改变和休克显著增加了死亡率。所有培养阳性病例均为 A 群脑膜炎奈瑟菌。所有脑膜炎球菌分离株对青霉素/氨苄西林、环丙沙星、头孢曲松、氯霉素和红霉素敏感，但有 1 株对氨苄西林和红霉素耐药。
