逍遥丸对行为绝望及应激性抑郁小鼠的影响
[Effects of Xiaoyao Wan on the behavioral despair and stress depression mice].
作者信息
Bao Li, Chen Jing, Huang Lin, Chen Wei, Lin Qing, Yao Xin-Sheng, Hiroshi Kurihara
机构信息
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
出版信息
Zhong Yao Cai. 2008 Sep;31(9):1360-4.
OBJECTIVE
To investigate the anti-depressant effect and the possible mechanism of Xiaoyao Wan in animal models.
METHODS
The open-field test and the forced swimming test were applied to study the anti-depressant effect of Xiaoyao Wan in mice, and HPLC-ECD was carried out to assay the contents of 5-HT and 5-HIAA, and the mechanism of Xiaoyao Wan on anti-depressant effect was discussed.
RESULTS
Xiaoyao Wan at the dose of 200, 400 and 600 mg/kg significantly increased the revolutions in force swimming test, and ameliorated brain cortex 5-HT and 5-HIAA content of restraint mice. But there was no effect on brain cortex 5-HT and 5-HIAA content of non-restraint mice.
CONCLUSION
Xiaoyao Wan has significant anti-depressant effect which may be related to the potentiation of brain serotonergic function.
目的
在动物模型中研究逍遥丸的抗抑郁作用及其可能机制。
方法
采用旷场试验和强迫游泳试验研究逍遥丸对小鼠的抗抑郁作用，运用高效液相色谱 - 电化学检测法测定5 - 羟色胺（5 - HT）和5 - 羟吲哚乙酸（5 - HIAA）的含量，并探讨逍遥丸抗抑郁作用的机制。
结果
逍遥丸200、400和600mg/kg剂量显著增加强迫游泳试验中的活动次数，改善束缚小鼠大脑皮质5 - HT和5 - HIAA含量。但对非束缚小鼠大脑皮质5 - HT和5 - HIAA含量无影响。
结论
逍遥丸具有显著抗抑郁作用，可能与增强脑内5 - 羟色胺能神经功能有关。
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