用于研究肌节性肌肉疾病的其他模式生物。
Other model organisms for sarcomeric muscle diseases.
作者信息
Sparrow John, Hughes Simon M, Segalat Laurent
机构信息
Department of Biology, University of York, York, UK.
出版信息
Adv Exp Med Biol. 2008;642:192-206. doi: 10.1007/978-0-387-84847-1_14.
Abstract
Model organisms are vital to our understanding of human muscle biology and disease. The potential of the nematode Caenorhabditis elegans, the fruitfly, Drosophila melanogaster and the zebrafish, Danio rerio, as model genetic organisms for the study of human muscle disease is discussed by examining their muscle biology, muscle genetics and development. The powerful genetic tools available with each organism are outlined. It is concluded that these organisms have already demonstrated potential in facilitating the study of muscle disease and in screening for therapeutic agents.
摘要
模式生物对于我们理解人类肌肉生物学和疾病至关重要。通过研究线虫秀丽隐杆线虫、果蝇黑腹果蝇和斑马鱼（丹尼奥氏鱼）的肌肉生物学、肌肉遗传学和发育，讨论了它们作为研究人类肌肉疾病的模式遗传生物的潜力。概述了每种生物可用的强大遗传工具。得出的结论是，这些生物已经在促进肌肉疾病研究和筛选治疗药物方面显示出潜力。
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