Lukić Dragoljub, Tamburella Claire, Buchegger Franz, Beyer Gerd-Jürgen, Comor Jozef J, Seimbille Yann
Laboratory of Radioisotopes, Vinca Institute of Nuclear Sciences, PO Box 522, 11001 Belgrade, Serbia.
Appl Radiat Isot. 2009 Apr;67(4):523-9. doi: 10.1016/j.apradiso.2008.12.008. Epub 2008 Dec 24.
As an intermediate half-life positron emitter (86)Y is an attractive radioisotope for positron emission tomography (PET) studies, particularly for patient specific dosimetry planning of (90)Y-based radiotherapy procedures. It can be conveniently produced by a small-sized cyclotron via the (86)Sr(p,n)(86)Y nuclear reaction. The optimization of the electrochemical separation of (86)Y from the target material and its purification was done by modeling the whole production cycle using (90)Y. The radionuclide was isolated using four electrodes in two electrolytic steps. In the first step two Pt plate anodes and a Pt Winkler cathode were used and the electro-deposition yield was determined in constant current mode of operation. In addition, the influence of pH on the efficiency of this first step was investigated. The second electrolysis, with Winkler electrode as anode and a Pt wire as cathode, was also performed in constant current mode of operation. The kinetics of recovery of the deposited activity on the Pt wire was investigated in acidic solutions. The optimized electrochemical method was then applied for (86)Y separation and purification. This modified procedure was proved to be faster and simpler than the previously proposed electrochemical techniques and is more convenient for automation of the routine production of (86)Y.
作为一种半衰期适中的正电子发射体，（86）钇是用于正电子发射断层扫描（PET）研究的一种有吸引力的放射性同位素，特别是在基于（90）钇的放射治疗程序的患者特异性剂量测定规划方面。它可以通过小型回旋加速器经由（86）锶（质子，中子）（86）钇核反应方便地产生。通过使用（90）钇对整个生产周期进行建模，对从靶材料中电化学分离（86）钇及其纯化进行了优化。使用四个电极通过两个电解步骤分离该放射性核素。在第一步中，使用两个铂板阳极和一个铂温克勒阴极，并在恒流操作模式下测定电沉积产率。此外，研究了pH对第一步效率的影响。第二步电解，以温克勒电极为阳极，铂丝为阴极，也在恒流操作模式下进行。在酸性溶液中研究了铂丝上沉积活性的回收动力学。然后将优化的电化学方法应用于（86）钇的分离和纯化。事实证明，这种改进的程序比先前提出的电化学技术更快、更简单，并且对于（86）钇的常规生产自动化更方便。
