Garud S, Leffler D, Dennis M, Edwards-George J, Saryan D, Sheth S, Schuppan D, Jamma S, Kelly C P
The Celiac Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Aliment Pharmacol Ther. 2009 Apr 15;29(8):898-905. doi: 10.1111/j.1365-2036.2009.03942.x.
Previous studies yielded conflicting results regarding the presence of an association between coeliac disease (CD) and psychiatric disorders including depression. This association has not been studied in the United States.
To determine the prevalence of psychiatric and autoimmune disorders in patients with CD in the US compared with control groups.
In a case control study, the prevalence of psychiatric and autoimmune disorders was compared in 600 CD patients, 200 irritable bowel syndrome (IBS) patients and 200 healthy controls.
The prevalence of depression in CD was 17.2% and was similar to that in IBS (18.5%, P = 0.74) and controls (16.0%, P = 0.79). Among CD patients, type I diabetes mellitus (DM) was identified as a significant risk factor for depression (P < 0.01) with 37% of patients with both CD and type I DM having clinical depression.
The prevalence of depression in CD is similar to that in other chronic gastrointestinal diseases and healthy controls. However, there is a markedly elevated risk of depression in patients with both type I DM and CD. Differing rates of type 1 DM among coeliac populations may account for disparity in published rates of depression in patients with CD.
先前的研究对于乳糜泻（CD）与包括抑郁症在内的精神疾病之间是否存在关联得出了相互矛盾的结果。在美国尚未对这种关联进行研究。
确定美国CD患者与对照组相比精神疾病和自身免疫性疾病的患病率。
在一项病例对照研究中，比较了600例CD患者、200例肠易激综合征（IBS）患者和200例健康对照者中精神疾病和自身免疫性疾病的患病率。
CD患者中抑郁症的患病率为17.2%，与IBS患者（18.5%，P = 0.74）和对照组（16.0%，P = 0.79）相似。在CD患者中，1型糖尿病（DM）被确定为抑郁症的一个显著危险因素（P < 0.01），37%同时患有CD和1型DM的患者患有临床抑郁症。
CD患者中抑郁症的患病率与其他慢性胃肠疾病和健康对照者相似。然而，同时患有1型DM和CD的患者患抑郁症的风险显著升高。乳糜泻人群中1型DM的不同发病率可能解释了已发表的CD患者抑郁症发病率的差异。
