Castro Patricia Dominguez, Harkin Grace, Hussey Mary, Christopher Brian, Kiat Clifford, Chin Jun Liong, Trimble Valerie, McNamara Deirdre, MacMathuna Padraic, Egan Brian, Ryan Barbara, Kevans David, Abuzakouk Mohamed, Farrell Richard, Feighery Con, Byrnes Valerie, Mahmud Nasir, McManus Ross
Trinity Translational Medicine Institute and Department of Clinical Medicine, Trinity Centre for Health Science, St James's Hospital, Dublin, Ireland.
Department of Clinical Medicine, University College Hospital Galway, Ireland.
United European Gastroenterol J. 2020 Mar;8(2):148-156. doi: 10.1177/2050640619899225. Epub 2020 Jan 7.
Coeliac disease (CD) is associated with an increased risk of other immune-mediated conditions. : To investigate the prevalence of coexistent immune-mediated diseases in CD patients, and changes in the prevalence of autoimmune thyroidal diseases over the last 50 years.
Medical record data were collected retrospectively from 749 CD patients in Ireland. Prevalence of autoimmune diseases was compared with previously published results from general populations. Patients were divided into four groups based on the year of diagnosis to analyse changes in the prevalence of autoimmune thyroidal disease over time.
Median age at the time of CD diagnosis was 56 years (range 18-91 years). A total of 233 (31.1%) patients had a coexistent immune-mediated condition (IMC). Autoimmune thyroidal diseases were seen in 149 (19.9%) patients, hypothyroidism in 110 (14.7%), type 1 diabetes in 27 (3.6%), psoriasis in 20 (2.7%), inflammatory bowel disease in 14 (1.9%) and rheumatoid arthritis in 12 (1.6%). All conditions were more common in CD patients than in the general population. Type 1 diabetes was diagnosed mainly before CD, whereas there was no such trend in other conditions. Autoimmune thyroidal diseases became less common in female CD patients over time.
Prevalence of autoimmune diseases is increased in adult CD patients compared with the general population. However, concomitant autoimmune thyroidal diseases became less common over time in women.
乳糜泻（CD）与其他免疫介导性疾病的风险增加相关。目的：调查CD患者中共存免疫介导性疾病的患病率，以及过去50年自身免疫性甲状腺疾病患病率的变化。
回顾性收集爱尔兰749例CD患者的病历数据。将自身免疫性疾病的患病率与先前发表的普通人群结果进行比较。根据诊断年份将患者分为四组，以分析自身免疫性甲状腺疾病患病率随时间的变化。
CD诊断时的中位年龄为56岁（范围18 - 91岁）。共有233例（31.1%）患者存在共存的免疫介导性疾病（IMC）。149例（19.9%）患者患有自身免疫性甲状腺疾病，110例（14.7%）患有甲状腺功能减退症，27例（3.6%）患有1型糖尿病，20例（2.7%）患有银屑病，14例（1.9%）患有炎症性肠病，12例（1.6%）患有类风湿性关节炎。所有疾病在CD患者中都比在普通人群中更常见。1型糖尿病主要在CD之前被诊断出来，而其他疾病则没有这种趋势。随着时间的推移，女性CD患者中自身免疫性甲状腺疾病变得不那么常见。
与普通人群相比，成年CD患者中自身免疫性疾病的患病率增加。然而，随着时间的推移，女性中并存的自身免疫性甲状腺疾病变得不那么常见。
