猫肿瘤病毒相关细胞膜抗原（FOCMA）：FOCMA与主要病毒粒子糖蛋白的区别
Feline oncornavirus-associated cell-membrane antigen (FOCMA): distinction between FOCMA and the major virion glycoprotein.
作者信息
Stephenson J R, Essex M, Hino S, Hardy W D, Aaronson S A
出版信息
Proc Natl Acad Sci U S A. 1977 Mar;74(3):1219-23. doi: 10.1073/pnas.74.3.1219.
Abstract
The humoral antibody response of feline leukemia virus (FeLV)-exposed cats to the feline oncornavirus-associated tumor cell-membrane antigen (FOCMA) is directly correlated with immunosurveillance against tumor development under natural conditions. By means of membrane immunofluorescence and radioimmunoprecipitation, the antibody response to FOCMA was found to be independent of the antibody response to the major envelope and core proteins of FeLV, gp70 and p30. This was especially true for healthy viremic cats, where antigenemia with circulating FeLV gp70 and p30 apparently binds any free antibody to these proteins, but high levels of FOCMA antibody are often concurrently present. Exhaustive in vitro absorption of highly immune nonviremic serum with gp70 and p30 also failed to remove FOCMA antibody activity. These results indicate that FOCMA is not one of these major FeLV structural proteins.
摘要
暴露于猫白血病病毒（FeLV）的猫对猫肿瘤病毒相关肿瘤细胞膜抗原（FOCMA）的体液抗体反应与自然条件下对肿瘤发展的免疫监视直接相关。通过膜免疫荧光和放射免疫沉淀法，发现对FOCMA的抗体反应独立于对FeLV主要包膜和核心蛋白gp70和p30的抗体反应。对于健康的病毒血症猫尤其如此，循环中的FeLV gp70和p30抗原血症显然会结合任何针对这些蛋白的游离抗体，但通常同时存在高水平的FOCMA抗体。用gp70和p30对高度免疫的非病毒血症血清进行彻底的体外吸收也未能去除FOCMA抗体活性。这些结果表明FOCMA不是这些主要的FeLV结构蛋白之一。
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