弗瑞德小鼠白血病病毒诱导产生的细胞表面抗原也存在于病毒粒子中。
Cell surface antigen induced by Friend murine leukemia virus is also in the virion.
作者信息
Friedman M, Lilly F, Nathenson S G
出版信息
J Virol. 1974 Nov;14(5):1126-31. doi: 10.1128/JVI.14.5.1126-1131.1974.
Abstract
Intact particles of Friend leukemia virus derived from infectious mouse serum absorb only trace amounts of cytotoxic anti-FMR antibodies, but physical disruption of the virions by freezing and thawing, by ether extraction or by detergent treatment releases large amounts of FMR antigenic activity. Thus this antigen, previously considered to occur mainly as a neo-antigen on the surfaces of virus-infected cells and as a soluble substance in the serum of infected mice, may be primarily a virion component.
摘要
源自感染性小鼠血清的弗瑞德白血病病毒完整颗粒仅吸附微量的细胞毒性抗FMR抗体，但通过冻融、乙醚提取或去污剂处理对病毒粒子进行物理破坏会释放大量FMR抗原活性。因此，这种抗原以前被认为主要作为病毒感染细胞表面的新抗原以及感染小鼠血清中的可溶性物质存在，现在可能主要是病毒粒子的一种成分。
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本文引用的文献
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OCCURRENCE OF SOLUBLE ANTIGEN IN THE PLASMA OF MICE WITH VIRUS-INDUCED LEUKEMIA.病毒诱导的白血病小鼠血浆中可溶性抗原的出现
Proc Natl Acad Sci U S A. 1964 Oct;52(4):950-8. doi: 10.1073/pnas.52.4.950.
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FORMATION OF CYTOXIC ANTIBODY AGAINST LEUKEMIAS INDUCED BY FRIEND VIRUS.抗Friend病毒诱导的白血病细胞毒性抗体的形成
Cancer Res. 1963 Aug;23:1063-8.
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Further electron microscope studies of a mouse leukemia induced by cell-free filtrates.对无细胞滤液诱导的小鼠白血病进行的进一步电子显微镜研究。
J Biophys Biochem Cytol. 1960 Jul;7(4):747-52. doi: 10.1083/jcb.7.4.747.
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Cellular antigen of Friend virus-induced leukemias.弗瑞德病毒诱导白血病的细胞抗原。
Cancer Res. 1968 Feb;28(2):338-42.
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Murine histocompatibility-2 (H-2) alloantigens. Purification and some chemical properties of soluble products from H-2b and H-2d genotypes released by papain digestion of membrane fractions.小鼠组织相容性-2（H-2）同种抗原。木瓜蛋白酶消化膜组分释放的H-2b和H-2d基因型可溶性产物的纯化及一些化学性质。
Biochemistry. 1969 Oct;8(10):4048-62. doi: 10.1021/bi00838a023.
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Antigens of tumors and leukemias induced by viruses.由病毒诱导产生的肿瘤和白血病的抗原。
Fed Proc. 1965 Sep-Oct;24(5):1009-17.
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Solubilization and partial purification of mouse histocompatibility antigens from a membranous lipoprotein fraction.从小鼠组织相容性抗原的膜脂蛋白组分中进行增溶和部分纯化。
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Immunology. 1974 Jan;26(1):37-48.
9
Studies on the FMR antigen.脆性X智力低下综合征抗原研究
Transplant Proc. 1969 Mar;1(1):85-9.
10
Host-range restrictions of murine leukemia viruses in mouse embryo cell cultures.小鼠胚胎细胞培养中小鼠白血病病毒的宿主范围限制
J Virol. 1970 Feb;5(2):221-5. doi: 10.1128/JVI.5.2.221-225.1970.
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