Neuss Heiko, Raue Wieland, Müller Verena, Weichert Wilko, Schwenk Wolfgang, Mall Julian W
Department of General, Visceral, Thoracic and Vascular Surgery, University Medicine Berlin, Charité Campus Mitte, Berlin, Germany.
Int J Colorectal Dis. 2009 May;24(5):551-7. doi: 10.1007/s00384-009-0643-0. Epub 2009 Jan 29.
We performed an experimental study in a rabbit model to investigate the effects of a selective Cox-2 inhibitor (Valdecoxib) on anastomotic healing following large bowel resection after 1 week.
Eighty New Zealand white rabbits were randomized into four groups and underwent a colon resection with end-to-end anastomosis. Group 1 (n = 20) was treated with Valdecoxib, group 2 with Metamizole (Novalgin), group 3 with Resveratrol (specific Cox-1 inhibitor), or a placebo vehicle with similar volume (group 4). Anastomotic healing was tested at the seventh postoperative day by measurement of the bursting pressure in vitro. Immunohistochemical staining of the anastomotic site was performed with polyclonal antibodies (CD31).
There were no significant differences in anastomotic dehiscence, bursting pressure, or vessel density between the treatment and control groups.
The application of Valdecoxib does not influence anastomotic healing or new vessel formation in the anastomotic region following large bowel resection.
我们在兔模型中进行了一项实验研究，以探讨选择性环氧化酶-2（Cox-2）抑制剂（伐地昔布）对大肠切除术后1周吻合口愈合的影响。
80只新西兰白兔随机分为四组，接受结肠端端吻合切除术。第1组（n = 20）用伐地昔布治疗，第2组用安乃近治疗，第3组用白藜芦醇（特异性Cox-1抑制剂）治疗，或用等体积的安慰剂（第4组）。术后第7天通过体外测量破裂压力来检测吻合口愈合情况。用多克隆抗体（CD31）对吻合部位进行免疫组织化学染色。
治疗组和对照组在吻合口裂开、破裂压力或血管密度方面无显著差异。
伐地昔布的应用不影响大肠切除术后吻合口愈合或吻合区域新血管形成。
