Leggio Lorenzo, Kenna George A, Fenton Miriam, Bonenfant Erica, Swift Robert M
Center for Alcohol and Addiction Studies, Department of Psychiatry and Human Behavior, Brown University, Box G S 121-4, Providence, RI 02912, USA.
Neuropsychol Rev. 2009 Mar;19(1):115-29. doi: 10.1007/s11065-008-9080-z. Epub 2009 Jan 31.
The goal of typology research is to identify subtypes of alcohol dependent (AD) patients sharing fundamental characteristics and try to match each subtype, with the most precise treatment strategy. This review provides a comprehensive history of the literature on alcohol dependent subtypes starting from the earliest attempt made by Jellinek. The binary models identified most closely with Cloninger and Babor as well as the successively more complex classifications are discussed. Typology classification potentially useful in guiding the treatment of AD patients, especially in the case of the serotonergic medications. Contrasting data suggests that other factors could influence the response to a medication and/or that more complex typologies should be identified. In summary, typology models may assist in the ascertainment criteria for clinical trials performed in behavioral and pharmacotherapeutic interventions. Greater emphasis, however, must be made to more clearly delineate this field of research, while moving toward more standardized typologies.
类型学研究的目标是识别具有基本特征的酒精依赖（AD）患者亚型，并尝试将每种亚型与最精确的治疗策略相匹配。本综述提供了从杰利内克最早的尝试开始的关于酒精依赖亚型的文献综合历史。讨论了与克隆宁格和巴伯最密切相关的二元模型以及相继更复杂的分类。类型学分类可能有助于指导AD患者的治疗，特别是在血清素能药物治疗的情况下。对比数据表明，其他因素可能影响对药物的反应和/或应识别更复杂的类型学。总之，类型学模型可能有助于确定行为和药物治疗干预临床试验的标准。然而，在朝着更标准化的类型学发展的同时，必须更加重视更清晰地界定这一研究领域。
